Description

Cftrinh-172 CAS NO 307510-92-5 is a potent and selective small-molecule inhibitor of the cystic fibrosis transmembrane conductance regulator (CFTR) protein. This compound is a critical research tool for studying chloride channel function, protein trafficking, and the pathophysiology of cystic fibrosis. It is essential for pharmaceutical R&D, academic research, and biotechnology applications focused on ion channel modulation and respiratory disease models.

Application

• Biomedical Research: A key pharmacological tool for investigating CFTR channel gating, conductance, and inhibition mechanisms in vitro and in vivo.
• Drug Discovery & Development: Used as a reference standard and lead compound in screening assays for developing novel CFTR-targeted therapeutics.
• Cystic Fibrosis Studies: Fundamental for creating disease models to understand CFTR dysfunction and evaluate potential corrective treatments.
• Cell Physiology & Signal Transduction: Employed in studies of epithelial ion and fluid transport, secretory processes, and cellular regulatory pathways.
• High-Throughput Screening (HTS): Serves as a control compound in automated assay systems to identify and characterize new modulators of chloride channel activity.

Basic Information

Product Name	Cftrinh-172
CAS No.	307510-92-5
Molecular Formula	C18H10F3N3O3S
Molecular Weight	405.35 g/mol
Synonyms	CFTRinh-172; 3-[(3-Trifluoromethyl)phenyl]-5-[(4-carboxyphenyl)methylene]-2-thioxo-4-thiazolidinone; CFTR Inhibitor 172; 2-Thioxo-4-thiazolidinone, 3-[3-(trifluoromethyl)phenyl]-5-[(4-carboxyphenyl)methylene]-; CFTRinh-172; CFTR inhibitor; CFTR channel blocker
EINECS	Contact for details

Quality Control

Our Cftrinh-172 is produced under strict quality management systems to ensure batch-to-batch consistency and reliability for research applications. Each lot undergoes comprehensive analytical characterization, including HPLC purity analysis, NMR and MS structural confirmation, and identity verification. A detailed Certificate of Analysis (COA) documenting purity, identity, and assay is provided with every shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. Allow the container to reach room temperature before opening to minimize moisture condensation. Store in a cool, dry, and well-ventilated area away from incompatible materials.

Specification

Item	Specification
Appearance	Yellow to orange solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.