Description

2,4-Difluorobenzylzinc Bromide is a highly reactive organozinc reagent, specifically a benzylzinc halide, widely used in modern synthetic organic chemistry. Its core value lies in enabling efficient carbon-carbon bond formation, particularly in the synthesis of complex, fluorinated aromatic compounds that are difficult to access via other routes. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials industries who require a reliable and high-purity building block for cross-coupling reactions.

Application

• Pharmaceutical Intermediate: A key reagent in Negishi and related cross-coupling reactions for constructing fluorinated biaryl and diarylmethane scaffolds found in active pharmaceutical ingredients (APIs).
• Agrochemical Synthesis: Used to introduce the 2,4-difluorobenzyl moiety into novel herbicide and fungicide molecules, leveraging fluorine's ability to modulate biological activity and stability.
• Ligand & Catalyst Development: Serves as a precursor for synthesizing specialized fluorinated ligands used in asymmetric catalysis and transition metal complexes.
• Material Science Research: Employed in the creation of fluorinated organic semiconductors, liquid crystals, and polymers where the difluorobenzyl group tunes electronic properties and intermolecular interactions.
• Custom & Contract Synthesis: A critical tool for custom synthesis houses and CROs (Contract Research Organizations) developing proprietary compounds for clients.
• Academic Research: Facilitates methodological development in organometallic chemistry and exploration of new synthetic pathways in university and institutional labs.

Basic Information

Item	Details
Product Name	2,4-Difluorobenzylzinc Bromide
CAS No.	307496-26-0
Molecular Formula	C7H5BrF2Zn
Molecular Weight	268.41 g/mol
Synonyms	(2,4-Difluorophenyl)methylzinc bromide; Zinc, bromo(2,4-difluorophenyl)methyl-; 2,4-Difluorobenzyl Zinc Bromide; (2,4-Difluorobenzyl)zinc bromide; Bromo(2,4-difluorobenzyl)zinc; 2,4-Difluorobenzylzinc bromide solution
EINECS	Contact for details

Quality Control

Every batch of 2,4-Difluorobenzylzinc Bromide is manufactured and tested under stringent quality protocols to ensure consistency and reliability for sensitive synthetic applications. We provide comprehensive Certificates of Analysis (COA) that detail critical parameters such as concentration (typically supplied as a solution in THF or other solvents), zinc content, and halide content. Our quality system is designed to meet the exacting standards of GMP and ISO-guided environments, ensuring traceability and purity for scale-up and regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. This material is both moisture-sensitive (hygroscopic) and easily oxidized; therefore, it must be stored under an inert atmosphere (argon or nitrogen) in its original sealed container. Recommended storage temperature is 2-8°C for extended stability. Keep away from heat, sparks, and open flame. Use only in a well-ventilated area or fume hood.

Specification

Item	Specification
Appearance	Colorless to pale yellow solution
Concentration	0.5 M in THF (or as specified)
Assay (Zn titration)	≥ 95%
Purity (NMR)	≥ 95%
Water Content (Karl Fischer)	≤ 100 ppm
Identification (IR / NMR)	Conforms to structure

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.