Description

Ethyl 3-(Chlorosulfonyl)Isonicotinate is a high-value, multi-functional chemical intermediate featuring both a chlorosulfonyl group and an ester moiety on a pyridine ring. This unique structure makes it a critical building block for the synthesis of complex molecules, particularly in the pharmaceutical and agrochemical sectors. It is primarily sought after by research chemists and process development scientists for constructing advanced sulfonamide derivatives and other active ingredients.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, especially those targeting enzymes where a sulfonamide pharmacophore is essential.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides that require a pyridine-sulfonamide core structure.
• Material Science Research: Serves as a monomer or functionalization agent for creating specialty polymers with specific surface properties or reactivity.
• Ligand and Catalyst Development: Employed in organic chemistry research to construct complex ligands for metal catalysis or molecular recognition.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences industry.

Basic Information

Product Name	Ethyl 3-(Chlorosulfonyl)Isonicotinate
CAS No.	306936-12-9
Molecular Formula	C8H8ClNO4S
Molecular Weight	249.67 g/mol
Synonyms	3-(Chlorosulfonyl)isonicotinic acid ethyl ester; Ethyl 3-chlorosulfonylisonicotinate; Ethyl 3-(chlorosulfonyl)-4-pyridinecarboxylate; Isonicotinic acid, 3-(chlorosulfonyl)-, ethyl ester; 4-Pyridinecarboxylic acid, 3-(chlorosulfonyl)-, ethyl ester; 306936-12-9; 3-Pyridinesulfonyl chloride, 4-(ethoxycarbonyl)-
EINECS	Contact for details

Quality Control

Every batch of Ethyl 3-(Chlorosulfonyl)Isonicotinate is manufactured under strict quality management systems. We provide comprehensive analytical data to ensure the material meets the precise requirements for advanced synthetic applications. A detailed Certificate of Analysis (COA) is supplied with each shipment, confirming identity, purity, and impurity profiles as determined by HPLC, NMR, and other relevant analytical techniques.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and consideration should be given to storage under an inert atmosphere for long-term preservation of quality.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.