Description

3-Keto-n-Aminoethyl-Naminocaproyldihydrocinnamoyl Cyclopamine is a high-purity, advanced synthetic derivative of the natural alkaloid cyclopamine, designed for targeted research and development applications. This compound is valued for its specific molecular structure, which is engineered to modulate key signaling pathways in biological systems. It is primarily utilized by researchers and developers in the pharmaceutical and biotechnology sectors, particularly in the fields of oncology, developmental biology, and regenerative medicine.

Application

• Pharmaceutical Research & Development: As a critical reference standard and active pharmaceutical ingredient (API) intermediate in the development of targeted cancer therapies.
• Biochemical Pathway Studies: For investigating and modulating the Hedgehog (Hh) signaling pathway in various in vitro and in vivo research models.
• Oncology Research: Used in preclinical studies to explore mechanisms of action against tumors where the Hh pathway is implicated.
• Stem Cell & Developmental Biology: A tool compound for studying cell differentiation, proliferation, and tissue patterning.
• High-Throughput Screening (HTS): Serves as a key component in assay development and validation for drug discovery campaigns.
• Chemical Synthesis: Acts as a sophisticated building block for the synthesis of novel analogs and conjugates with enhanced properties.

Basic Information

Product Name	3-Keto-n-Aminoethyl-Naminocaproyldihydrocinnamoyl Cyclopamine
CAS No.	306387-90-6
Molecular Formula	C36H55N3O5
Molecular Weight	609.85 g/mol
Synonyms	Cyclopamine derivative KADCC; 3-Keto-NAENAC-DHC-Cyclopamine; 11-Deoxojervine Conjugate; Hedgehog Pathway Inhibitor Derivative; Keto-Aminoethyl-Aminocaproyl-Dihydrocinnamoyl Cyclopamine; 3-Oxo-N-(2-aminoethyl)-N-[6-(3,4-dihydrocinnamamido)hexanoyl]cyclopamine; (22R,25R)-3-Oxo-5α-spirostan-12-en-11-one Conjugate; KAENAC-DHC-CPA
EINECS	Contact for details

Quality Control

Our 3-Keto-n-Aminoethyl-Naminocaproyldihydrocinnamoyl Cyclopamine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements for research-grade materials. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting purity, assay, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. Consider storing under an inert atmosphere for long-term preservation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Assay	≥ 97.0% (on anhydrous basis)
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.