Description

Sphingosine Kinase Inhibitor, Ski-I CAS NO 306301-68-8 is a potent and selective small-molecule inhibitor of sphingosine kinase (SphK), a key enzyme in the sphingolipid metabolic pathway. This compound is a critical research tool for modulating cellular sphingosine-1-phosphate (S1P) levels, which are implicated in critical processes like cell proliferation, survival, and migration. It is primarily utilized by researchers in pharmaceutical R&D and academic institutions for investigating cancer biology, inflammatory diseases, and fibrosis, offering a pathway to validate novel therapeutic targets.

Application

• Biomedical Research: Fundamental tool for studying the role of the sphingosine kinase/S1P axis in cellular signaling pathways.
• Oncology Research: Used in in vitro and in vivo studies to investigate the inhibition of tumor growth, angiogenesis, and metastasis.
• Inflammation & Immunology Studies: Applied to explore the mechanisms of inflammatory responses and immune cell regulation.
• Fibrosis Research: Utilized in models to understand and inhibit pathological tissue scarring in organs.
• Drug Discovery & Development: Serves as a pharmacological probe and lead compound for developing novel SphK-targeted therapeutics.
• Academic & Institutional Laboratories: Essential reagent for grant-funded research exploring sphingolipid metabolism.

Basic Information

Product Name	Sphingosine Kinase Inhibitor, Ski-I
CAS No.	306301-68-8
Molecular Formula	C₂₀H₂₀N₄O₂
Molecular Weight	348.40 g/mol
Synonyms	SKI-I; 2-(p-Hydroxyanilino)-4-(p-chlorophenyl)thiazole; Sphingosine Kinase Inhibitor I; (2Z)-2-(4-Hydroxyanilino)-4-(4-chlorophenyl)-4-thiazoline-2-thione; NVP-231; BML-231; SphK Inhibitor I
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Each batch of Sphingosine Kinase Inhibitor (Ski-I) is characterized using advanced analytical techniques to confirm identity, purity, and potency. Certificates of Analysis (COA) detailing batch-specific results for assay, purity (HPLC), and related substances are available upon request. We adhere to strict quality management protocols suitable for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere for long-term stability. This compound is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture condensation. For short-term use, store desiccated at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%
Solubility	Soluble in DMSO, DMF; sparingly soluble in ethanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.