Description

4-(3-Chloro-4-Fluorophenylamino)-6-Fluoro-1,7-Naphthyridine-3-Carbonitrile is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound is of significant commercial importance for its role in the synthesis of targeted therapeutic agents, particularly kinase inhibitors. It is primarily required by research institutions and pharmaceutical manufacturers engaged in the development of novel oncology and anti-inflammatory treatments.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of potent and selective kinase inhibitors for targeted cancer therapies.
• Oncology Research: Used in preclinical and clinical research for developing novel small-molecule drugs targeting specific signaling pathways.
• Medicinal Chemistry: Serves as a core scaffold for structure-activity relationship (SAR) studies to optimize drug potency and selectivity.
• API Development: Employed in the process development and scale-up of active pharmaceutical ingredients (APIs) for various therapeutic areas.
• Biochemical Research: Utilized as a tool compound in biochemical assays to study enzyme inhibition and cellular mechanisms.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.

Basic Information

Product Name	4-(3-Chloro-4-Fluorophenylamino)-6-Fluoro-1,7-Naphthyridine-3-Carbonitrile
CAS No.	305371-33-9
Molecular Formula	C15H7ClF2N4
Molecular Weight	316.69 g/mol
Synonyms	4-[(3-Chloro-4-fluorophenyl)amino]-6-fluoro-1,7-naphthyridine-3-carbonitrile; 6-Fluoro-4-((3-chloro-4-fluorophenyl)amino)-1,7-naphthyridine-3-carbonitrile; 305371-33-9; 4-(3-Chloro-4-fluoroanilino)-6-fluoro-1,7-naphthyridine-3-carbonitrile; N-(3-Chloro-4-fluorophenyl)-6-fluoro-3-cyano-1,7-naphthyridin-4-amine
EINECS	Contact for details

Quality Control

Our production of 4-(3-Chloro-4-Fluorophenylamino)-6-Fluoro-1,7-Naphthyridine-3-Carbonitrile adheres to stringent quality management systems, ensuring batch-to-batch consistency for critical research and development applications. All material is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles, generated using validated analytical methods such as HPLC, GC, and NMR. We operate in compliance with cGMP guidelines where applicable to support our clients' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). This compound is light-sensitive (store away from light) and may be hygroscopic (moisture-sensitive); therefore, containers should be kept sealed under an inert atmosphere if specified for long-term storage.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.