Description

[6-Fluoro-4-(3-Nitrilopropionyl)Pyridin-3-Yl]Carbamic Acid tert-Butyl Ester is a high-purity, advanced pharmaceutical intermediate designed for the synthesis of complex active pharmaceutical ingredients (APIs). This compound is valued for its role as a key building block in medicinal chemistry, enabling the efficient construction of molecules with specific biological targets. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of new therapeutic agents, particularly in oncology and other specialized drug discovery programs.

Application

• Pharmaceutical Intermediate: A critical building block in the multi-step synthesis of novel Active Pharmaceutical Ingredients (APIs).
• Drug Discovery & Medicinal Chemistry: Used in research and development for constructing molecular libraries and lead optimization candidates.
• Oncology Research: Serves as a precursor in the development of targeted cancer therapies and kinase inhibitors.
• Contract Manufacturing (CMO/CDMO): Supplied to contract research and manufacturing organizations for cGMP-compliant API production.
• Process Chemistry Development: Employed in scaling up synthetic routes from laboratory to pilot and commercial scale.
• Chemical Reference Standard: Used as a high-purity standard for analytical method development and quality control.

Basic Information

Product Name	[6-Fluoro-4-(3-Nitrilopropionyl)Pyridin-3-Yl]Carbamic Acid tert-Butyl Ester
CAS No.	305371-16-8
Molecular Formula	C13H14FN3O3
Molecular Weight	279.27 g/mol
Synonyms	tert-Butyl N-[6-fluoro-4-(3-cyanopropanoyl)pyridin-3-yl]carbamate; 3-{5-[(tert-Butoxycarbonyl)amino]-2-fluoropyridin-4-yl}-3-oxopropanenitrile; 6-Fluoro-4-(3-cyanopropanoyl)pyridin-3-yl carbamic acid tert-butyl ester; BOC-protected 3-(5-amino-2-fluoropyridin-4-yl)-3-oxopropanenitrile; 305371-16-8; (6-Fluoro-4-(3-cyanopropanoyl)pyridin-3-yl)carbamic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our [6-Fluoro-4-(3-Nitrilopropionyl)Pyridin-3-Yl]Carbamic Acid tert-Butyl Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment supports applications requiring material traceability and compliance with ICH guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.