Description

Dynasore CAS NO 304448-55-3 is a potent, cell-permeable small molecule inhibitor of dynamin, a key GTPase involved in clathrin-mediated endocytosis and other vesicle formation processes. This compound matters significantly for researchers as it provides a powerful tool to selectively block endocytic pathways, enabling the study of cellular uptake mechanisms, receptor trafficking, and viral entry. It is essential for scientists in pharmaceutical R&D, academic biochemistry and cell biology labs, and biotechnology companies focused on neurobiology, virology, and intracellular signaling.

Application

• Biochemical Research: A critical tool for studying the mechanisms of clathrin-mediated endocytosis (CME) and dynamin-dependent processes in live cells.
• Neurobiology Studies: Used to investigate synaptic vesicle recycling, neurotransmitter receptor internalization, and neuronal signaling pathways.
• Virology & Infectious Disease Research: Employed to inhibit the cellular entry of viruses that utilize endocytic pathways, helping to elucidate infection mechanisms.
• Cell Signaling Analysis: Facilitates the study of growth factor receptor (e.g., EGFR) trafficking and downstream signal transduction.
• Drug Discovery Screening: Serves as a reference compound or positive control in assays designed to identify novel inhibitors of endocytosis or dynamin.
• Cancer Research: Applied to explore the role of endocytosis in oncogenic signaling, tumor progression, and the cellular uptake of therapeutics.

Basic Information

Product Name	Dynasore
CAS No.	304448-55-3
Molecular Formula	C₁₈H₁₄N₂O₄
Molecular Weight	322.32 g/mol
Synonyms	N-(3,4-Dihydroxybenzylidene)hydroxylamine; Dynasore, Inhibitor; 3-Hydroxy-4-[(E)-(2-hydroxy-3-methoxybenzylidene)amino]benzonitrile; Dynamin Inhibitor I; (E)-N'-(3,4-Dihydroxybenzylidene)benzohydrazide (common mis-assignment); Endocytosis Inhibitor Dynasore
EINECS	Contact for details

Quality Control

Our Dynasore is produced under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity confirmation and identity verification by spectroscopic methods. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting the exact specifications and test results.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant use.

Specification

Item	Specification
Appearance	Yellow to orange solid
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.