Description

(1’R,2S)-2-(1’,2’-Dihydroxyethyl)-6-Fluorochromane is a high-purity chiral fluorinated chromane derivative, serving as a critical advanced pharmaceutical intermediate. Its precise stereochemistry and functional groups make it a valuable building block for synthesizing complex bioactive molecules. This compound is essential for research and development laboratories and production facilities in the pharmaceutical and fine chemical sectors, particularly those focused on novel therapeutics.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the development and production of active pharmaceutical ingredients (APIs), especially in central nervous system (CNS) and cardiovascular drug candidates.
• Asymmetric Synthesis: Utilized in stereoselective synthesis due to its defined (1’R,2S) configuration, enabling the construction of molecules with high enantiomeric purity.
• Medicinal Chemistry Research: Serves as a core scaffold or precursor for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• Fluorine Chemistry: The 6-fluoro substitution makes it a valuable compound for investigating the effects of fluorine introduction on pharmacokinetics and metabolic stability.
• Process Chemistry Development: Used in scaling up and optimizing synthetic routes for more efficient and cost-effective manufacturing of target molecules.

Basic Information

Item	Details
Product Name	(1’R,2S)-2-(1’,2’-Dihydroxyethyl)-6-Fluorochromane
CAS No.	303176-39-8
Molecular Formula	C₁₁H₁₃FO₄
Molecular Weight	228.22 g/mol
Synonyms	6-Fluoro-(1'R,2S)-2-(1',2'-dihydroxyethyl)chromane; (1'R,2S)-rel-2-(1',2'-Dihydroxyethyl)-6-fluorochromane; 6-Fluoro-2-[(1R,2S)-1,2-dihydroxyethyl]chroman; (1R,2S)-2-(1,2-Dihydroxyethyl)-6-fluorochromane; Fluorochromane diol derivative; CAS 303176-39-8
EINECS	Contact for details

Quality Control

Every batch of (1’R,2S)-2-(1’,2’-Dihydroxyethyl)-6-Fluorochromane is manufactured under strict quality management systems. We provide comprehensive analytical data to ensure the product meets the high standards required for pharmaceutical development. A Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles by HPLC is supplied with each shipment, supporting compliance with cGMP guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.