Description

Pyridine,3,4-Difluoro-,1-Oxide(9Ci) is a fluorinated pyridine N-oxide derivative, a high-value intermediate in advanced organic synthesis. Its core value lies in its unique structure, which combines the directing properties of the N-oxide group with the electronic effects of fluorine atoms, enabling precise chemical transformations. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries developing novel active ingredients, particularly where the introduction of fluorine is critical for enhancing metabolic stability and bioavailability.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of fluorinated drug candidates, including kinase inhibitors and central nervous system (CNS) active compounds.
• Agrochemical Synthesis: Used in the research and development of new-generation herbicides and pesticides, where fluorine atoms improve efficacy and environmental profile.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in transition metal catalysis and organocatalysis.
• Material Science Research: Employed in the synthesis of fluorinated organic semiconductors and electronic materials.
• Chemical Research & Development: A versatile reagent for exploring novel fluorination reactions and constructing complex heterocyclic systems in academic and industrial R&D.

Basic Information

Product Name	Pyridine,3,4-Difluoro-,1-Oxide(9Ci)
CAS No.	303154-05-4
Molecular Formula	C5H3F2NO
Molecular Weight	131.08 g/mol
Synonyms	3,4-Difluoropyridine 1-Oxide; 3,4-Difluoropyridine N-Oxide; 3,4-Difluoropyridine-1-oxide; Pyridine, 3,4-difluoro-, 1-oxide; 1-Oxido-3,4-difluoropyridin-1-ium; Difluoropyridine N-Oxide
EINECS	Contact for details

Quality Control

Our Pyridine,3,4-Difluoro-,1-Oxide(9Ci) is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the exacting standards required for research and process chemistry. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.