Description

Ethyl 4-(2-Fluorophenyl)-2-Methyl-6-Oxo-1,4,5,6-Tetrahydro-3-Pyridinecarboxylate is a high-purity, advanced pharmaceutical intermediate characterized by its specific dihydropyridine core structure. This compound matters for its critical role as a key building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly in cardiovascular and neurological research. Pharmaceutical manufacturers and advanced R&D laboratories need this material for developing next-generation therapeutic agents, where consistent quality and reliable supply are paramount.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of novel dihydropyridine-class calcium channel blockers and other therapeutic agents.
• Cardiovascular Drug Research: Used in the R&D of new medications targeting hypertension, angina, and other cardiovascular conditions.
• Neurological Drug Development: Serves as a precursor in the creation of compounds for treating neurological disorders.
• Chemical Synthesis Reference Standard: Employed as a high-purity standard for analytical method development and quality control in API manufacturing.
• Academic & Contract Research: Utilized in university and CRO settings for medicinal chemistry programs and structure-activity relationship (SAR) studies.
• Process Chemistry & Scale-Up: Integral to process optimization and pilot-scale synthesis during the drug development lifecycle.

Basic Information

Product Name	Ethyl 4-(2-Fluorophenyl)-2-Methyl-6-Oxo-1,4,5,6-Tetrahydro-3-Pyridinecarboxylate
CAS No.	303139-43-7
Molecular Formula	C15H16FNO3
Molecular Weight	277.29 g/mol
Synonyms	Ethyl 4-(2-fluorophenyl)-2-methyl-6-oxo-1,4,5,6-tetrahydro-3-pyridinecarboxylate; 1,4-Dihydro-2-methyl-4-(2-fluorophenyl)-6-oxo-3,5-pyridinedicarboxylic acid 3-ethyl ester; 3-Carbethoxy-4-(2-fluorophenyl)-2-methyl-6-oxo-1,4,5,6-tetrahydropyridine; 4-(2-Fluorophenyl)-2-methyl-6-oxo-1,4,5,6-tetrahydro-3-pyridinecarboxylic acid ethyl ester; DHP Derivative with 2-Fluorophenyl Substituent; 303139-43-7; Fluorophenyl DHP Ester
EINECS	Contact for details

Quality Control

Our Ethyl 4-(2-Fluorophenyl)-2-Methyl-6-Oxo-1,4,5,6-Tetrahydro-3-Pyridinecarboxylate is manufactured under a strict quality management system to ensure batch-to-batch consistency suitable for pharmaceutical R&D and scale-up. Production adheres to current Good Manufacturing Practices (cGMP) where applicable, and the material is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). The container should be kept tightly sealed in a dry environment to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.