Description

2,5-Bis(Trifluoromethyl)Benzyl Bromide is a high-value organofluorine building block characterized by its reactive benzyl bromide group flanked by two electron-withdrawing trifluoromethyl substituents. This unique structure makes it a critical intermediate for synthesizing advanced materials and active pharmaceutical ingredients (APIs) where the introduction of lipophilic, metabolically stable trifluoromethyl groups is required. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty materials sectors.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in medicinal chemistry for introducing CF3 groups to enhance metabolic stability and membrane permeability.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides where the trifluoromethyl moiety improves biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorine-containing compounds used in electronic displays and organic light-emitting diodes (OLEDs) due to its ability to modify electronic properties.
• Ligand & Catalyst Development: Employed in the preparation of specialized ligands for catalysis, particularly in cross-coupling reactions prevalent in fine chemical manufacturing.
• Polymer & Resin Modifier: Incorporated into polymer chains to impart unique properties such as chemical resistance, low surface energy, and thermal stability.
• Advanced Material Research: Utilized in academic and industrial R&D for creating novel fluorinated aromatic compounds with tailored properties for specialized applications.

Basic Information

Product Name	2,5-Bis(Trifluoromethyl)Benzyl Bromide
CAS No.	302911-98-4
Molecular Formula	C10H5BrF6
Molecular Weight	319.05 g/mol
Synonyms	α-Bromo-2,5-bis(trifluoromethyl)toluene; 1-(Bromomethyl)-2,5-bis(trifluoromethyl)benzene; (2,5-Bis(trifluoromethyl)phenyl)methyl bromide; 2,5-Bis(trifluoromethyl)benzyl bromide; Benzene, 1-(bromomethyl)-2,5-bis(trifluoromethyl)-; 2,5-Di(trifluoromethyl)benzyl bromide
EINECS	Contact for details

Quality Control

Our 2,5-Bis(Trifluoromethyl)Benzyl Bromide is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from strong acids and incompatible materials. Due to the light-sensitive nature and reactivity of the benzyl bromide moiety, it is recommended to store under an inert atmosphere for long-term stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.