Description

Atocalcitol CAS NO 302904-82-1 is a synthetic vitamin D3 analog, specifically a calcitriol derivative, designed for high-purity pharmaceutical research and development. This compound is of significant interest for its targeted biological activity, offering a valuable tool for studying and modulating vitamin D receptor pathways. It is primarily utilized by pharmaceutical manufacturers and advanced research institutions engaged in the development of novel therapeutics for conditions related to calcium metabolism and cell proliferation.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of advanced active pharmaceutical ingredients (APIs) targeting vitamin D pathways.
• Research & Development: Used as a reference standard and biochemical tool in preclinical studies to investigate vitamin D receptor (VDR) agonism and related signaling mechanisms.
• Dermatological Research: Explored in the development of topical treatments for psoriasis and other hyperproliferative skin disorders due to its modulatory effects on keratinocyte differentiation.
• Metabolic Disorder Studies: Applied in research models for secondary hyperparathyroidism, osteoporosis, and other disorders of bone and mineral metabolism.
• Oncological Research: Investigated for its potential antiproliferative and differentiating effects in certain cancer cell lines.
• Chemical Synthesis: Employed by fine chemical manufacturers for the custom synthesis of more complex vitamin D analogs and prodrugs.

Basic Information

Item	Detail
Product Name	Atocalcitol
CAS No.	302904-82-1
Molecular Formula	C₂₇H₄₄O₃
Molecular Weight	416.64 g/mol
Synonyms	1α,24-Dihydroxy-22-oxavitamin D3; 1α,24-Dihydroxy-22-oxacalcitriol; 22-Oxa-1α,24-dihydroxyvitamin D3; 22-Oxacalcitriol; 1α,24R-Dihydroxy-22-oxavitamin D3; Atocalcitolum; OCT
EINECS	Contact for details

Quality Control

Our Atocalcitol is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development purposes. Each lot undergoes comprehensive analytical testing, including identity confirmation by spectroscopic methods and purity determination by HPLC. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture absorption. For long-term storage, consider inert gas purging.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.