Description

5-(Trifluoromethyl)Pyridine-2-Carboxamidine is a high-value, nitrogen-containing heterocyclic building block characterized by its reactive amidine group and trifluoromethyl substituent. This compound is essential for medicinal chemistry and agrochemical research, where it serves as a key precursor for synthesizing novel active pharmaceutical ingredients (APIs) and crop protection agents. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of kinase inhibitors, antiviral agents, and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, leveraging the bioactivity of the pyridine-amidine core.
• Chemical Research & Development: Serves as a versatile synthon in organic synthesis for constructing fused heterocycles and complex amines.
• Ligand and Catalyst Preparation: Utilized in the preparation of specialized ligands for metal catalysis and coordination chemistry.
• Material Science Precursor: Potential use in the synthesis of functionalized polymers and advanced organic electronic materials.

Basic Information

Product Name	5-(Trifluoromethyl)Pyridine-2-Carboxamidine
CAS No.	302899-35-0
Molecular Formula	C7H6F3N3
Molecular Weight	189.14 g/mol
Synonyms	2-Carbamimidoyl-5-(trifluoromethyl)pyridine; 5-(Trifluoromethyl)-2-pyridinecarboxamidine; 5-(Trifluoromethyl)picolinamidine; 2-Pyridinecarboxamidine, 5-(trifluoromethyl)-; 302899-35-0; 5-Trifluoromethylpyridine-2-carboxamidine; Amidino-5-trifluoromethyl-2-pyridine
EINECS	Contact for details

Quality Control

Our 5-(Trifluoromethyl)Pyridine-2-Carboxamidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment supports applications requiring high-purity intermediates for research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.