Description

Sb 431542 CAS NO 301836-41-9 is a potent and selective small molecule inhibitor of the TGF-β type I receptor ALK5, widely used in biochemical and pharmacological research. This compound is critical for studying cellular signaling pathways, particularly those involving TGF-β, which plays a key role in cell growth, differentiation, and apoptosis. It is an essential research tool for scientists and institutions in the fields of oncology, stem cell biology, fibrosis research, and drug discovery.

Application

• Biochemical Research: Used as a selective inhibitor to study TGF-β/Activin/Nodal signaling pathways and their downstream effects.
• Stem Cell Studies: Facilitates the maintenance of pluripotency in embryonic stem cells by inhibiting differentiation signals.
• Oncology Research: Investigates the role of TGF-β signaling in tumor progression, metastasis, and the tumor microenvironment.
• Fibrosis Research: Serves as a key tool in models of cardiac, renal, and pulmonary fibrosis to explore therapeutic interventions.
• Drug Discovery: Used in high-throughput screening and as a reference compound for developing novel ALK5 inhibitors.
• Cell Culture & Differentiation: Applied in protocols to direct cell fate and study mesendoderm induction and epithelial-mesenchymal transition (EMT).

Basic Information

Product Name	Sb 431542
CAS No.	301836-41-9
Molecular Formula	C22H18N4O3
Molecular Weight	386.41 g/mol
Synonyms	SB-431542; SB431542; 4-[4-(1,3-Benzodioxol-5-yl)-5-(2-pyridinyl)-1H-imidazol-2-yl]-benzamide; 2-(4-(Benzol[d][1,3]dioxol-5-yl)-5-(pyridin-2-yl)-1H-imidazol-2-yl)benzamide; ALK5 Inhibitor II; TGF-β RI Kinase Inhibitor II; TGF-β Receptor I Kinase Inhibitor
EINECS	Contact for details

Quality Control

Our Sb 431542 is manufactured under strict quality management systems to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant standards for research chemicals, and specifications can be provided to meet the stringent requirements of pharmaceutical and academic research.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry, cool place. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and potency. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	Off-white to pale yellow solid
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%
Solubility	Soluble in DMSO, DMF; slightly soluble in ethanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.