Description

Ent-Estriol is a high-purity, enantiomerically pure stereoisomer of the natural estrogen hormone estriol, identified by CAS NO 300853-07-0. This compound is of significant value in advanced pharmaceutical research and development, particularly for studying stereospecific biological interactions and metabolic pathways. It serves as a critical reference standard and a key chiral building block for researchers and manufacturers in the pharmaceutical, biotechnology, and advanced chemical synthesis sectors.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for analytical method development, validation, and quality control of steroidal APIs and finished products.
• Biochemical Research: Essential for in-vitro and in-vivo studies investigating the structure-activity relationships (SAR) of estrogen receptors, enabling the development of selective receptor modulators.
• Chiral Intermediate: Acts as a high-value starting material or intermediate in the asymmetric synthesis of novel steroid-based therapeutics and diagnostic agents.
• Endocrinology Studies: Utilized in clinical and preclinical research to understand the physiological and pharmacological effects of specific estrogen enantiomers.
• Diagnostic Kit Development: Employed in the formulation and calibration of immunoassays and other diagnostic tests for hormonal analysis.

Basic Information

Product Name	Ent-Estriol
CAS No.	300853-07-0
Molecular Formula	C18H24O3
Molecular Weight	288.38 g/mol
Synonyms	(+)-Estriol; (16R,17R)-Estra-1,3,5(10)-triene-3,16,17-triol; ent-Estra-1,3,5(10)-triene-3,16,17-triol; Enantiomer of Estriol; 16α,17β-Estriol enantiomer; Estriol enantiomer
EINECS	Contact for details

Quality Control

Our Ent-Estriol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for research and pharmaceutical applications. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee identity, purity, and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.