Description

2-Fluoro-4-Iodotoluene is a versatile halogenated aromatic building block of significant importance in advanced organic synthesis. Its unique structure, featuring both fluorine and iodine substituents on a toluene backbone, makes it a critical intermediate for constructing complex molecules. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for applications in cross-coupling reactions and the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds requiring fluorinated and iodinated aromatic systems.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides where the fluorine atom enhances biological activity and metabolic stability.
• Material Science Research: Serves as a monomer or building block for developing specialty polymers and liquid crystals with tailored electronic or optical properties.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed reactions like Suzuki, Stille, and Negishi couplings, enabling the construction of biaryl and complex aromatic structures.
• Chemical Research & Development: Employed in academic and industrial R&D labs for exploring new synthetic methodologies and creating compound libraries for screening.
• Ligand and Catalyst Preparation: Useful for synthesizing specialized ligands and organometallic catalysts used in homogeneous catalysis.

Basic Information

Product Name	2-Fluoro-4-Iodotoluene
CAS No.	39998-81-7
Molecular Formula	C7H6FI
Molecular Weight	236.03 g/mol
Synonyms	1-Fluoro-2-iodo-4-methylbenzene; 4-Methyl-2-fluoro-1-iodobenzene; 2-Fluoro-1-iodo-4-methylbenzene; 2-Fluoro-4-methyl-1-iodobenzene; 4-Iodo-3-fluorotoluene; Toluene, 2-fluoro-4-iodo-; 2-Fluoro-4-iodotoluol
EINECS	Contact for details

Quality Control

Our 2-Fluoro-4-Iodotoluene is manufactured under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC/GC)	≥97.0% (Standard Grade)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.