Description

2,2,2-Trifluoro-n-[(R)-α-Methylbenzyl]Acetamide is a high-value, chiral trifluoroacetamide derivative that serves as a critical chiral auxiliary and building block in advanced organic synthesis. Its importance lies in its ability to impart stereochemical control and introduce the metabolically stable trifluoromethyl group into target molecules, which is a key strategy in modern pharmaceutical design. This compound is primarily needed by research and development chemists and process development teams in the pharmaceutical, agrochemical, and specialty chemical industries for the synthesis of enantiomerically pure active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of enantiomerically pure active pharmaceutical ingredients (APIs), particularly those requiring a trifluoromethyl group for enhanced metabolic stability and bioavailability.
• Chiral Auxiliary: Used in asymmetric synthesis to control the stereochemistry of new chiral centers, enabling the production of single enantiomer compounds.
• Agrochemical Research: Employed in the development of advanced, optically active herbicides, fungicides, and insecticides where specific stereochemistry is crucial for activity and environmental safety.
• Ligand and Catalyst Preparation: Serves as a precursor for the synthesis of novel chiral ligands and organocatalysts used in catalytic asymmetric reactions.
• Material Science: Investigated as a monomer or modifier for creating specialty polymers with unique optical or surface properties due to the fluorine content.
• Academic & Contract Research: A valuable reagent for methodological development in organic chemistry and for custom synthesis projects in contract research organizations (CROs).

Basic Information

Product Name	2,2,2-Trifluoro-n-[(R)-α-Methylbenzyl]Acetamide
CAS No.	39995-50-1
Molecular Formula	C11H12F3NO
Molecular Weight	231.21 g/mol
Synonyms	(R)-N-(1-Phenylethyl)-2,2,2-trifluoroacetamide; (R)-α-Methylbenzyl Trifluoroacetamide; (R)-1-Phenylethyl Trifluoroacetamide; (R)-N-(α-Methylbenzyl)trifluoroacetamide; (R)-TFA-α-Methylbenzylamine; (R)-1-Phenylethylamine Trifluoroacetamide; (R)-PEA-TFA; (R)-N-(1-Phenylethyl)-2,2,2-trifluoroethanamide
EINECS	Contact for details

Quality Control

Our 2,2,2-Trifluoro-n-[(R)-α-Methylbenzyl]Acetamide is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Products undergo rigorous quality testing, including chiral purity analysis by HPLC, to ensure compliance with industry standards for advanced intermediates. Certificates of Analysis (COA) detailing identity, purity, and chiral excess are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (R-enantiomer)
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.