Description

16-Methyl Prostaglandin E2 is a synthetic analog of the naturally occurring prostaglandin E2, distinguished by a methyl group at the 16-position. This structural modification enhances its metabolic stability and biological activity profile, making it a valuable research biochemical and pharmaceutical intermediate. It is primarily utilized in advanced life science research and the development of therapeutic agents targeting inflammation, smooth muscle contraction, and reproductive health.

Application

• Pharmaceutical Research & Development: A key intermediate in the synthesis of novel prostaglandin-based therapeutics for ocular, cardiovascular, and gastrointestinal applications.
• Biochemical Research: Used as a potent, selective ligand to study prostaglandin E receptor (EP receptor) subtypes and their signaling pathways in vitro and in vivo.
• Cell Culture & Physiology Studies: Employed to investigate the role of prostaglandins in processes such as inflammation, pain perception, and uterine contractility.
• Veterinary Medicine Development: Investigated for applications in animal health, particularly in areas of reproductive management and anti-inflammatory treatments.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method validation in pharmaceutical manufacturing and regulatory testing.

Basic Information

Product Name	16-Methyl Prostaglandin E2
CAS No.	39746-14-0
Molecular Formula	C₂₂H₃₆O₅
Molecular Weight	380.52 g/mol
Synonyms	16-Methyl PGE2; 16-Methylprostaglandin E2; 11α,15α-Dihydroxy-16-methyl-9-oxoprosta-5,13-dien-1-oic acid; 16-Me-PGE2; 16-Methyl-dinoprostone; (5Z,13E)-(9S,11R,15S)-11,15-Dihydroxy-16-methyl-9-oxoprosta-5,13-dien-1-oic acid
EINECS	Contact for details

Quality Control

Our 16-Methyl Prostaglandin E2 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the stringent requirements for research and development use. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability, consistency, and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. Allow the sealed container to reach room temperature before opening to minimize moisture condensation. Keep away from strong acids and bases.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.