Description

Pepstatin CAS NO 39324-30-6 is a potent, naturally occurring protease inhibitor that specifically targets aspartic proteases such as pepsin, renin, and cathepsin D. This specificity makes it an indispensable biochemical tool for research and development in enzymology and proteomics. It is primarily utilized by pharmaceutical researchers, diagnostic kit manufacturers, and academic institutions for studying protease mechanisms, developing therapeutic agents, and controlling proteolytic degradation in biological samples.

Application

• Biochemical Research: A critical reagent for inhibiting aspartic proteases in enzyme kinetics studies and mechanistic investigations.
• Pharmaceutical Development: Used in drug discovery programs targeting aspartic proteases involved in diseases like hypertension (renin) and Alzheimer's (BACE-1).
• Diagnostic Manufacturing: Incorporated into diagnostic assay kits and buffers to prevent sample degradation by proteases, ensuring assay stability and accuracy.
• Cell Culture & Protein Purification: Added to cell lysis buffers and protein extraction protocols to protect proteins of interest from proteolytic cleavage.
• Academic & Industrial Laboratories: Serves as a standard control and experimental tool in life science research across various disciplines.

Basic Information

Product Name	Pepstatin
CAS No.	39324-30-6
Molecular Formula	C34H63N5O9
Molecular Weight	685.90 g/mol
Synonyms	Pepstatin A; Isovaleryl-Val-Val-Sta-Ala-Sta; (3S,4S)-4-Amino-3-hydroxy-6-methylheptanoic Acid (1S,2S)-1-(((2S,3S)-3-Amino-2-hydroxy-4-phenylbutanoyl)amino)-2-methylbutyl Ester; Aspartic Protease Inhibitor; Microbial Protease Inhibitor; STATIVAL; NSC 134714
EINECS	Contact for details

Quality Control

Our Pepstatin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and biological activity assays. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to ensure traceability and compliance with your research or production standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0 %
Biological Activity	≥ 90% of reference standard

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.