Description

L(-)-10-Camphorsulfonyl Chloride is a high-purity, chiral sulfonyl chloride derivative of camphor, serving as a critical chiral auxiliary and building block in asymmetric synthesis. Its value lies in enabling the introduction of the bulky, optically active camphorsulfonyl (camphorsulfonamide) group, which is instrumental for inducing stereoselectivity and resolving racemic mixtures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries, particularly for developing active pharmaceutical ingredients (APIs) and advanced intermediates.

Application

• Chiral Auxiliary in Asymmetric Synthesis: Used to prepare camphorsulfonamide derivatives for diastereoselective reactions, including alkylations, aldol additions, and Diels-Alder reactions.
• Pharmaceutical Intermediate: A key precursor in the synthesis of chiral drugs, especially those targeting central nervous system (CNS) disorders, cardiovascular diseases, and antiviral agents.
• Catalyst and Ligand Preparation: Employed in the synthesis of chiral catalysts and ligands for transition metal-catalyzed asymmetric transformations.
• Resolution of Racemic Amines and Alcohols: Facilitates the separation of enantiomers via diastereomeric salt or derivative formation.
• Agrochemical Synthesis: Used in creating enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Material Science Research: Serves as a building block for chiral polymers and advanced organic materials with specific optical properties.

Basic Information

Product Name	L(-)-10-Camphorsulfonyl Chloride
CAS No.	39262-22-1
Molecular Formula	C10H15ClO3S
Molecular Weight	250.74 g/mol
Synonyms	(-)-10-Camphorsulfonyl Chloride; (1S,4S)-(-)-10-Camphorsulfonyl Chloride; L-(-)-Camphor-10-sulfonyl Chloride; (1S)-(-)-Camphor-10-sulfonyl Chloride; (1S,4S)-1,7,7-Trimethylbicyclo[2.2.1]heptane-2-sulfonyl Chloride; (-)-Camphor-10-sulfonyl Chloride; L-Camphorsulfonyl Chloride; (1S)-Camphorsulfonyl Chloride
EINECS	Contact for details

Quality Control

Our L(-)-10-Camphorsulfonyl Chloride is manufactured under strict quality control protocols to ensure high chiral purity and chemical integrity, suitable for demanding synthetic applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing key parameters such as enantiomeric excess (ee), chemical purity, and identity confirmation. We adhere to cGMP principles where applicable, and our quality systems are designed to meet the stringent requirements of pharmaceutical R&D and production.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (ee) (Chiral HPLC)	≥ 99.0%
Melting Point	64 - 68 °C
Specific Rotation [α]20/D	-20° to -24° (c=1 in CHCl3)
Heavy Metals (as Pb)	≤ 20 ppm
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.