Description

3,5-Bis(Trifluoromethyl)Benzenesulfonyl Chloride is a high-value, multi-functional chemical intermediate characterized by its reactive sulfonyl chloride group and electron-withdrawing trifluoromethyl substituents. This compound is essential for introducing the highly lipophilic and metabolically stable bis(trifluoromethyl)phenylsulfonyl moiety into target molecules. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical sectors for the synthesis of advanced active ingredients, sulfonamides, and specialty materials where enhanced bioavailability and chemical resistance are critical.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly protease inhibitors, kinase inhibitors, and other small molecule therapeutics.
• Agrochemical Synthesis: Used in creating advanced herbicides, fungicides, and insecticides that benefit from the stability and lipophilicity of the CF3 groups.
• Material Science: Serves as a monomer or cross-linking agent in the production of specialty polymers, coatings, and resins with unique chemical and thermal resistance properties.
• Sulfonamide Library Production: A crucial reagent in combinatorial chemistry and high-throughput screening for generating diverse sulfonamide libraries for biological evaluation.
• Ligand and Catalyst Development: Employed in the preparation of specialized ligands for catalysis and metal-organic frameworks (MOFs).

Basic Information

Product Name	3,5-Bis(Trifluoromethyl)Benzenesulfonyl Chloride
CAS No.	39234-86-1
Molecular Formula	C8H3ClF6O2S
Molecular Weight	312.61 g/mol
Synonyms	3,5-Bis(trifluoromethyl)benzenesulfonyl chloride; 1,3-Bis(trifluoromethyl)-5-benzenesulfonyl chloride; α,α,α,α',α',α'-Hexafluoro-3,5-xylene-ω-sulfonyl chloride; Benzenesulfonyl chloride, 3,5-bis(trifluoromethyl)-; 3,5-Di(trifluoromethyl)benzenesulfonyl chloride; 3,5-Bis(trifluoromethyl)phenylsulfonyl chloride; 3,5-BTFBSCl
EINECS	Contact for details

Quality Control

Our 3,5-Bis(Trifluoromethyl)Benzenesulfonyl Chloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure high purity and consistent performance. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.