Description

4-Nitro-3-(Trifluoromethyl)Benzenesulfonyl Chloride is a versatile and highly reactive sulfonyl chloride derivative, serving as a critical building block in advanced organic synthesis. Its value lies in the unique combination of a strongly electron-withdrawing nitro group and a trifluoromethyl group, which makes it an excellent electrophile for introducing functionalized aryl sulfonyl moieties. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for the development of active ingredients, dyes, and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of sulfonamide-based drugs, including enzyme inhibitors and receptor antagonists.
• Agrochemical Synthesis: Used in creating novel herbicides, fungicides, and insecticides that benefit from the enhanced bioactivity and metabolic stability imparted by the trifluoromethyl and sulfonyl groups.
• Dyestuff and Pigment Manufacturing: Acts as a reactive intermediate for producing high-performance, color-fast azo dyes and pigments.
• Polymer Chemistry: Employed as a monomer or cross-linking agent to introduce sulfonyl functionalities into specialty polymers, enhancing their thermal and chemical resistance.
• Chemical Research & Development: A valuable reagent for medicinal chemistry and material science research, facilitating structure-activity relationship (SAR) studies and the discovery of new compounds.
• Ligand and Catalyst Preparation: Useful for synthesizing specialized ligands and organocatalysts used in asymmetric synthesis and transition metal catalysis.

Basic Information

Product Name	4-Nitro-3-(Trifluoromethyl)Benzenesulfonyl Chloride
CAS No.	39234-83-8
Molecular Formula	C7H3ClF3NO4S
Molecular Weight	289.61 g/mol
Synonyms	3-(Trifluoromethyl)-4-nitrobenzenesulfonyl chloride; 4-Nitro-α,α,α-trifluoro-m-toluenesulfonyl chloride; 1-Nitro-2-(trifluoromethyl)-5-chlorosulfonylbenzene; 2-(Trifluoromethyl)-4-nitrobenzenesulfonyl chloride; 4-Nitro-3-trifluoromethylbenzenesulfonyl chloride; NSC 403819; Benzenesulfonyl chloride, 4-nitro-3-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Our production of 4-Nitro-3-(Trifluoromethyl)Benzenesulfonyl Chloride adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing to ensure high purity and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting key parameters such as assay, identity, and impurity profiles. We are committed to meeting the exacting standards required for research and commercial-scale synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to prevent decomposition. Keep away from strong bases, oxidizing agents, and sources of ignition.

Specification

Item	Specification
Appearance	Off-white to pale yellow crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.