Description

Acetoacetic Acid-3-14C Ethyl Ester is a carbon-14 labeled derivative of ethyl acetoacetate, serving as a crucial radiolabeled building block for metabolic and pharmacokinetic studies. Its primary value lies in enabling precise tracking of molecular pathways in biological systems, providing critical data for research and development. This compound is essential for scientists and researchers in the pharmaceutical, agrochemical, and life science sectors who require high-purity isotopic tracers.

Application

• Tracer in Metabolic Pathway Analysis: Used to study the biosynthesis and degradation of fatty acids and ketone bodies in vivo.
• Drug Metabolism and Pharmacokinetics (DMPK): A key intermediate for synthesizing radiolabeled drug candidates to track absorption, distribution, metabolism, and excretion (ADME).
• Biochemical Research: Employed as a labeled precursor in enzymatic studies and the synthesis of complex natural products.
• Agrochemical Development: Utilized in the research of pesticide and herbicide metabolism within plants and environmental systems.
• Synthetic Intermediate: Acts as a versatile, labeled synthon for preparing more complex carbon-14 labeled compounds for various research applications.

Basic Information

Product Name	Acetoacetic Acid-3-14C Ethyl Ester
CAS No.	39169-78-3
Molecular Formula	C6H1014CO3
Molecular Weight	~132.13 g/mol (based on 12C; actual varies with 14C specific activity)
Synonyms	Ethyl 3-oxo[3-14C]butanoate; Ethyl [3-14C]acetoacetate; [3-14C]Acetoacetic Acid Ethyl Ester; Ethyl 3-oxobutanoate-3-14C; Ethyl β-ketobutyrate-3-14C; 1-Ethoxy-1-oxobutan-2-one-3-14C; Carbon-14 Labeled Ethyl Acetoacetate
EINECS	Contact for details

Quality Control

Every batch of Acetoacetic Acid-3-14C Ethyl Ester is produced and analyzed under strict quality protocols to ensure the highest standards of radiochemical purity and chemical identity. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing specific activity, radiochemical purity (typically >97% by HPLC), chemical purity, and solvent content are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at recommended temperatures between 2°C and 8°C (refrigerated) or as specified on the label. Keep the container in a well-ventilated area, away from strong acids and organic solvents. For long-term storage, consider conditions recommended for radioactive materials.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow liquid
Identification (IR / NMR)	Conforms to structure
Specific Activity	Customizable (mCi/mmol)
Radiochemical Purity (HPLC)	≥ 97%
Chemical Purity (GC / HPLC)	≥ 95%
Solvent (by 1H NMR)	As specified (e.g., Benzene, Toluene)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.