Description

4-Fluoropyridine Hydrochloride is a versatile fluorinated heterocyclic building block essential for advanced organic synthesis. This compound matters because it serves as a key intermediate for introducing the 4-fluoropyridyl moiety, a privileged structure in medicinal chemistry and material science. It is primarily needed by research and development chemists in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in developing kinase inhibitors, receptor modulators, and other bioactive molecules.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides, herbicides, and fungicides where the fluoropyridine scaffold enhances biological activity and stability.
• Ligand and Catalyst Development: Employed in organometallic chemistry to create novel ligands for catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Serves as a precursor for fluorinated polymers, liquid crystals, and electronic materials requiring specific fluorine-substituted aromatic systems.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes and tags for studying biological systems and diagnostic applications.
• Custom Synthesis and Contract Manufacturing: A valuable starting material for custom synthesis projects and scale-up processes in fine chemical production.

Basic Information

Product Name	4-Fluoropyridine Hydrochloride
CAS No.	39160-31-1
Molecular Formula	C5H5ClFN
Molecular Weight	133.55 g/mol
Synonyms	4-Fluoropyridine HCl; 4-Fluoropyridine Hydrochloride Salt; 4-Fluoropyridinium Chloride; Pyridine, 4-fluoro-, hydrochloride; 4-Fluoropyridine monohydrochloride; 4-FPy·HCl; 4-Fluoropyridine HCl salt; 4-Fluoropyridin-1-ium chloride
EINECS	Contact for details

Quality Control

Our 4-Fluoropyridine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and FTIR, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for advanced intermediates, ensuring traceability and consistency for critical R&D and scale-up applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.