Description

(-)-N2'-Deacetyl-N2'-(2-Methyl-1-Oxopropyl)Maytansine is a potent synthetic derivative of the natural cytotoxin maytansine, engineered for enhanced stability and targeted therapeutic action. This compound is a critical intermediate and payload in the development of Antibody-Drug Conjugates (ADCs), a revolutionary class of targeted cancer therapies. It is primarily utilized by pharmaceutical R&D teams, biotech companies, and contract manufacturing organizations (CMOs) specializing in oncology drug development and advanced bioconjugation technologies.

Application

• Primary Payload for Antibody-Drug Conjugates (ADCs): Serves as the cytotoxic warhead conjugated to monoclonal antibodies for targeted cancer therapy.
• Oncology Research & Development: Used in preclinical and clinical studies to evaluate the efficacy and mechanism of novel ADC constructs.
• Bioconjugation Chemistry Studies: A key molecule for developing and optimizing linker-payload technologies and conjugation methodologies.
• Reference Standard: Employed as a high-purity analytical standard for quality control and regulatory filings of ADC-based pharmaceuticals.
• Synthesis of Maytansinoid Analogues: Acts as a versatile intermediate for the chemical synthesis of other modified maytansine derivatives with tailored properties.

Basic Information

Product Name	(-)-N2'-Deacetyl-N2'-(2-Methyl-1-Oxopropyl)Maytansine
CAS No.	38997-10-3
Molecular Formula	C35H48ClN3O9
Molecular Weight	690.22 g/mol
Synonyms	DM1; mertansine; N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine precursor; Ansamitocin P-3 derivative; Maytansinoid DM1; NSC 332598; (3R,4S,5S,6R)-6-[(2S)-2-[(3R,4S,5S)-4-[(2S,3R)-3-Hydroxy-2-methylbutanoyl]oxy-3-methoxy-5-methyloxan-2-yl]oxy-4-methyl-1-oxopentan-2-yl]-5-methoxy-4-methyl-1-oxa-4-azacycloheptadec-6-ene-3,7,17-trione
EINECS	Contact for details

Quality Control

Our (-)-N2'-Deacetyl-N2'-(2-Methyl-1-Oxopropyl)Maytansine is manufactured under strict quality systems suitable for pharmaceutical development. Each batch is subjected to rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the exacting standards required for ADC payload synthesis. A comprehensive Certificate of Analysis (COA) detailing purity, related substances, and residual solvents is provided with every shipment to support your regulatory and R&D needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize condensation and moisture uptake. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.