Description

Propylbenzilylcholine Mustard Hydrochloride is a potent, irreversible muscarinic acetylcholine receptor (mAChR) antagonist, widely recognized as a key pharmacological tool compound. Its primary value lies in its ability to alkylate and permanently block muscarinic receptors, making it indispensable for receptor mapping, density studies, and the investigation of receptor turnover. This high-purity biochemical is essential for researchers and developers in pharmaceutical R&D, neuropharmacology, and academic neuroscience laboratories.

Application

• Pharmacological Research: Irreversible blockade of muscarinic acetylcholine receptors (M1-M5) for functional studies.
• Receptor Mapping & Autoradiography: Used as a radioligand precursor (e.g., [³H]-PrBCM) for quantifying receptor density and distribution in tissues.
• Neurochemical Studies: Investigating the role of muscarinic signaling in learning, memory, and cognitive disorders.
• Drug Discovery & Development: A critical tool for validating targets and screening compounds in cholinergic pathways.
• Toxicology & Safety Pharmacology: Studying the long-term effects of cholinergic system modulation.
• Biochemical Assay Development: Serving as a standard or control in assay systems designed to measure receptor binding and function.

Basic Information

Product Name	Propylbenzilylcholine Mustard Hydrochloride
CAS No.	38770-09-1
Molecular Formula	C₁₆H₂₅ClN₂O•HCl
Molecular Weight	333.30 g/mol
Synonyms	PrBCM; Propylbenzilylcholine Mustard; Benzilylcholine Mustard Propyl Derivative; 2-[[(2S)-2-Hydroxy-3-propylaminopropyl]methylamino]ethyl Benzilate Mustard Hydrochloride; 4-(N,N-Bis(2-chloroethyl)amino)benziloylcholine; Muscarinic Receptor Alkylating Agent; Mustard analog of Propylbenzilylcholine
EINECS	Contact for details

Quality Control

Our Propylbenzilylcholine Mustard Hydrochloride is manufactured under strict quality systems to ensure batch-to-batch consistency and reliability for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to stringent in-house specifications aligned with the needs of pharmacological research, ensuring the product's performance in receptor binding and functional assays.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. The compound is easily oxidized and moisture-sensitive; allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation. For long-term stability, store desiccated at -20°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.