Description

4-Methoxybenzylmagnesium Chloride is a versatile organometallic reagent, specifically a Grignard reagent, widely used in organic synthesis for the introduction of the 4-methoxybenzyl (PMB) protecting group or as a nucleophile for carbon-carbon bond formation. Its value lies in its ability to act as a powerful carbon nucleophile, enabling the efficient synthesis of complex molecules in pharmaceutical and fine chemical research. This compound is essential for R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced material sectors who require high-purity intermediates for constructing target molecules.

Application

• As a key nucleophilic reagent in the synthesis of pharmaceutical intermediates and active pharmaceutical ingredients (APIs).
• For the introduction of the 4-methoxybenzyl (PMB) protecting group for alcohols and phenols in multi-step organic synthesis.
• In the construction of carbon-carbon bonds through reactions with carbonyl compounds (aldehydes, ketones, esters) and epoxides.
• As a building block for the synthesis of liquid crystals and advanced organic materials.
• For research and development of agrochemicals and specialty chemicals.
• In academic and industrial R&D laboratories for methodological studies in organometallic chemistry.

Basic Information

Product Name	4-Methoxybenzylmagnesium Chloride
CAS No.	38769-92-5
Molecular Formula	C8H9ClMgO
Molecular Weight	180.91 g/mol
Synonyms	p-Methoxybenzylmagnesium Chloride; (4-Methoxyphenyl)methylmagnesium Chloride; PMB-MgCl; Magnesium, chlorido(4-methoxyphenyl)methyl-; 4-Methoxybenzyl Grignard Reagent; 4-Methoxybenzylmagnesium Chloride Solution; (4-Methoxybenzyl)magnesium Chloride
EINECS	Contact for details

Quality Control

Our 4-Methoxybenzylmagnesium Chloride is produced and handled under stringent quality protocols to ensure batch-to-batch consistency and reliability for critical synthetic applications. We employ advanced analytical techniques, including titration and GC/HPLC, to verify concentration, purity, and reactivity. A comprehensive Certificate of Analysis (COA) detailing assay, solvent content, and other critical parameters is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. This product is hygroscopic (moisture-sensitive) and easily oxidized; it must be stored under an inert atmosphere (argon or nitrogen) in a cool, dry place. For solutions, store at recommended temperatures (typically 2-8°C or as specified) in the original sealed container. Keep away from heat, sparks, open flames, and incompatible materials such as water, acids, and oxidizing agents.

Specification

Item	Specification
Appearance (Solution)	Clear, colorless to light yellow
Concentration (in THF or Ether)	0.5 M - 2.0 M (Customizable)
Assay (by Titration)	≥ 95%
Identification (IR/NMR)	Conforms to structure

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.