Description

(+)-Bicuculline Methochloride CAS NO 38641-83-7 is a potent and selective competitive antagonist of the GABAA receptor, widely recognized as a crucial pharmacological tool in neuroscience research. Its primary value lies in its ability to block inhibitory neurotransmission, making it indispensable for studying synaptic function, neuronal excitability, and the mechanisms of convulsants. This high-purity compound is essential for researchers and scientists in the fields of neuropharmacology, electrophysiology, and the development of central nervous system (CNS) therapeutics.

Application

• Neuroscience Research: Fundamental tool for investigating GABAergic inhibition, synaptic plasticity, and neuronal network behavior in vitro and in vivo.
• Electrophysiology Studies: Used to block GABAA receptor-mediated currents in patch-clamp experiments to isolate excitatory postsynaptic potentials (EPSPs).
• Pharmacological Screening: Serves as a reference standard and positive control in assays designed to discover novel GABAA receptor modulators or anticonvulsant drugs.
• Convulsant Mechanism Studies: Employed to induce and study seizure models for understanding epilepsy and evaluating potential antiepileptic agents.
• Biochemical Assays: Used in receptor binding studies (e.g., competitive displacement assays) to characterize ligand-receptor interactions at the GABAA site.
• Academic & Institutional Research: Critical reagent for universities and research institutes focused on neurobiology, cellular signaling, and CNS disorders.

Basic Information

Product Name	(+)-Bicuculline Methochloride
CAS No.	38641-83-7
Molecular Formula	C₂₁H₂₂ClNO₆
Molecular Weight	419.86 g/mol
Synonyms	(+)-Bicuculline Methochloride; Bicuculline Methochloride; (S)-Bicuculline Methochloride; NSC 224994; 1(S),9(R)-Bicuculline Methochloride; (1S,9R)-10-[(5S)-5,6,7,8-Tetrahydro-5-methyl-5,8-dioxo-6-furo[3,4-g]isoquinolin-6-ium-3-yl]-10-azatricyclo[7.3.1.0²,⁷]trideca-2,4,6-trien-4-ol Chloride
EINECS	Contact for details

Quality Control

Our (+)-Bicuculline Methochloride is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for critical research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and stringent controls for residual solvents and moisture. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all specifications and test results to support your research and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and potency. For long-term storage, consider desiccant in the container.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Specific Rotation	+130° to +135° (c=1 in H₂O)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.