Description

n-Hydroxyphentermine is a key organic intermediate and derivative of phentermine, characterized by the introduction of a hydroxyl group to its chemical structure. This modification is crucial for fine-tuning pharmacological activity and metabolic pathways in advanced research and development. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the synthesis of novel therapeutic agents and reference standards. The compound serves as a vital building block for medicinal chemists exploring new chemical entities.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the research and synthesis of potential central nervous system (CNS) active compounds and appetite suppressants.
• Metabolite Standard: Used as a reference standard in analytical laboratories for drug metabolism and pharmacokinetic (DMPK) studies related to phentermine.
• Medicinal Chemistry Research: Employed as a building block for structure-activity relationship (SAR) studies to develop new chemical entities with modified biological profiles.
• Biochemical Research: Utilized in studies investigating adrenergic receptor interactions and neurotransmitter analog synthesis.
• Fine Chemical Synthesis: Acts as a specialized intermediate in custom synthesis projects for contract research organizations (CROs) and academic institutions.

Basic Information

Product Name	n-Hydroxyphentermine
CAS No.	38473-30-2
Molecular Formula	C10H15NO
Molecular Weight	165.23 g/mol
Synonyms	4-Hydroxyphentermine; 1-Phenyl-2-methyl-2-aminopropan-1-ol; α,α-Dimethyl-β-hydroxy-phenethylamine; p-Hydroxyphentermine; 2-Amino-1-phenyl-2-methyl-1-propanol; Phentermine hydroxyl metabolite; 1-Phenyl-2-methyl-2-aminopropanol
EINECS	Contact for details

Quality Control

Our n-Hydroxyphentermine is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis to ensure it meets the stringent requirements for research and development applications. Certificates of Analysis (COA) detailing all test results are provided with every shipment to guarantee traceability and compliance with your internal quality standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.