Description

2-Fluoro-6-Hydroxybenzaldehyde is a versatile fluorinated aromatic aldehyde that serves as a critical building block in advanced organic synthesis. Its unique structure, featuring both a formyl group and a phenolic hydroxyl group ortho to a fluorine atom, enables precise molecular modifications essential for developing high-value compounds. This intermediate is particularly valuable for researchers and manufacturers in the pharmaceutical and agrochemical sectors seeking to incorporate fluorine into target molecules to enhance their biological activity, metabolic stability, and physical properties.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), especially for fluorinated drug candidates targeting central nervous system (CNS) disorders, anti-inflammatory agents, and antimicrobials.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and pesticides where the introduction of fluorine improves lipophilicity, bioavailability, and environmental persistence.
• Ligand and Catalyst Development: Serves as a starting material for creating sophisticated chelating ligands and organocatalysts used in asymmetric synthesis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of specialty polymers, liquid crystals, and organic electronic materials where fluorinated aromatic units are required to tune electronic properties and thermal stability.
• Fluorescent Probe and Dye Chemistry: Acts as a core structure for synthesizing fluorophores and molecular probes used in bio-imaging and diagnostic assays.
• Academic and R&D Laboratories: A valuable reagent for methodological studies in organic chemistry, particularly in reactions involving directed ortho-metalation and nucleophilic aromatic substitution.

Basic Information

Product Name	2-Fluoro-6-Hydroxybenzaldehyde
CAS No.	38226-10-7
Molecular Formula	C7H5FO2
Molecular Weight	140.11 g/mol
Synonyms	6-Fluoro-2-hydroxybenzaldehyde; 2-Fluoro-6-hydroxybenzenecarboxaldehyde; 2-Hydroxy-6-fluorobenzaldehyde; 6-Fluorosalicylaldehyde; Salicylaldehyde, 6-fluoro-; 2-Fluoro-6-hydroxy-benzaldehyde; 2-Fluor-6-hydroxybenzaldehyd; 38226-10-7
EINECS	Contact for details

Quality Control

Our 2-Fluoro-6-Hydroxybenzaldehyde is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and FTIR, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, documenting all critical parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most demanding synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This compound is easily oxidized (store under inert atmosphere) and is light-sensitive (store away from light). Keep away from heat, sparks, and open flame. For long-term storage, consider packaging under an inert gas such as nitrogen or argon.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Melting Point	95 - 99 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.