Description

7,8-Dihydroxyflavone (CAS NO 38183-03-8) is a potent and selective small-molecule agonist of the tropomyosin receptor kinase B (TrkB), the primary receptor for brain-derived neurotrophic factor (BDNF). This compound is of significant interest for its ability to mimic the neurotrophic and neuroprotective effects of BDNF, making it a critical research tool in neuroscience and pharmacology. It is primarily utilized by researchers and developers in the pharmaceutical, biotechnology, and academic sectors for studying neurogenesis, synaptic plasticity, and potential therapeutic applications for neurological disorders.

Application

• Neuroscience Research: A key pharmacological tool for studying BDNF/TrkB signaling pathways, neuroprotection, and neuronal differentiation.
• Drug Discovery & Development: Serves as a lead compound or reference standard in the development of novel therapeutics for neurodegenerative diseases (e.g., Alzheimer's, Parkinson's) and mood disorders.
• Biochemical Assays: Used in high-throughput screening (HTS) and in vitro cell-based assays to investigate TrkB receptor activation and downstream effects.
• Academic & Preclinical Studies: Employed in animal models to explore cognitive enhancement, memory formation, and recovery from neural injury.
• Reference Standard: Acts as a high-purity analytical standard for quality control and method validation in analytical laboratories.
• Cellular Biology: Used to promote neuronal survival and outgrowth in primary neuronal cultures and stem cell differentiation protocols.

Basic Information

Product Name	7,8-Dihydroxyflavone
CAS No.	38183-03-8
Molecular Formula	C₁₅H₁₀O₄
Molecular Weight	254.24 g/mol
Synonyms	7,8-DHF; 7,8-Dihydroxy-2-phenyl-4H-chromen-4-one; 7,8-Dihydroxy-2-phenyl-4H-1-benzopyran-4-one; 2-Phenyl-7,8-dihydroxy-4H-chromen-4-one; TrkB Agonist; BDNF Mimetic; Flavone, 7,8-dihydroxy-
EINECS	Contact for details

Quality Control

Our 7,8-Dihydroxyflavone is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all specifications and test results to support your research integrity and regulatory compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	Yellow to light brown powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm
Solubility	Soluble in DMSO, Ethanol; Slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.