Description

S-(4-Nitrobenzyl)-6-Thioinosine is a specialized nucleoside analog derivative, recognized for its role as a potent inhibitor of the equilibrative nucleoside transporter 1 (ENT1). This compound is of significant value in biochemical and pharmacological research, particularly in studies related to nucleoside transport mechanisms and cancer cell metabolism. It is primarily sought by researchers and developers in the fields of oncology research, medicinal chemistry, and molecular biology for investigating drug resistance and developing targeted therapeutic strategies.

Application

• Biochemical Research: Used as a selective inhibitor of ENT1 to study nucleoside salvage pathways and cellular uptake mechanisms.
• Oncology & Cancer Research: Investigated for its potential to modulate the efficacy of nucleoside analog chemotherapeutic agents by inhibiting their cellular extrusion.
• Medicinal Chemistry & Drug Discovery: Serves as a key intermediate or reference standard in the synthesis and development of novel nucleoside-based pharmaceuticals.
• Cell Biology Studies: Employed in in vitro assays to understand the role of nucleoside transporters in cell physiology and under hypoxic conditions.
• Enzyme Inhibition Studies: Utilized to probe the activity and function of enzymes involved in purine metabolism.
• Academic Research: A critical tool for universities and research institutes focusing on transporter biology and metabolic disorders.

Basic Information

Product Name	S-(4-Nitrobenzyl)-6-Thioinosine
CAS No.	38048-32-7
Molecular Formula	C₁₇H₁₇N₅O₆S
Molecular Weight	419.42 g/mol
Synonyms	6-[(4-Nitrobenzyl)thio]-9H-purin-9-yl-β-D-ribofuranoside; 6-[(4-Nitrobenzyl)thio]-9-β-D-ribofuranosyl-9H-purine; NBMPR; Nitrobenzylthioinosine; S-(p-Nitrobenzyl)-6-thioinosine; 6-(4-Nitrobenzylthio)inosine; ENT1 Inhibitor
EINECS	Contact for details

Quality Control

Our S-(4-Nitrobenzyl)-6-Thioinosine is produced under stringent quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity verification, NMR and MS for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with research-grade specifications. We support cGMP-compliant manufacturing for advanced applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is light-sensitive (store away from light). For long-term storage, consider desiccated conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.