Description

4-Fluorobenzylmagnesium Chloride 0.25M is a versatile organometallic reagent, specifically a Grignard reagent, supplied as a standardized solution in tetrahydrofuran (THF). This compound is a critical building block for introducing the 4-fluorobenzyl group into target molecules, enabling efficient carbon-carbon bond formation. It is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries who require high-purity intermediates for synthesis.

Application

• Pharmaceutical Intermediate Synthesis: Key reagent for constructing active pharmaceutical ingredients (APIs), particularly in the development of fluorinated compounds which often exhibit enhanced metabolic stability and bioavailability.
• Agrochemical Manufacturing: Used in the synthesis of novel herbicides, fungicides, and insecticides where the fluorobenzyl moiety can improve efficacy and environmental profile.
• Ligand and Catalyst Preparation: Serves as a precursor for specialized ligands used in asymmetric catalysis and transition metal complexes.
• Material Science Research: Employed in the synthesis of fluorinated polymers, liquid crystals, and organic electronic materials to modify physical properties.
• Fine Chemical Production: Facilitates the scalable synthesis of complex, high-value fluorinated aromatic compounds for various industrial applications.
• Academic & R&D Laboratories: A fundamental tool for methodological development and exploratory synthesis in organic chemistry.

Basic Information

Item	Detail
Product Name	4-Fluorobenzylmagnesium Chloride 0.25M
CAS No.	38046-82-1
Molecular Formula	C7H6ClFMg
Molecular Weight	168.87 g/mol
Synonyms	(4-Fluorophenyl)methylmagnesium Chloride; 4-Fluorobenzylmagnesium Chloride solution; p-Fluorobenzylmagnesium Chloride; 1-(Chloromagnesio)methyl-4-fluorobenzene; Magnesium, chloromethyl(4-fluorophenyl)-; Grignard Reagent, 4-Fluorobenzylmagnesium Chloride; 4-Fluoro-benzylmagnesium chloride; (4-Fluorobenzyl)magnesium chloride
EINECS	Contact for details

Quality Control

Every batch of our 4-Fluorobenzylmagnesium Chloride 0.25M solution is manufactured and analyzed under stringent quality control protocols to ensure consistency and reliability for your synthetic workflows. We guarantee precise molarity and high chemical purity, with testing typically including titration for Grignard concentration and GC analysis for solvent and reagent quality. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment and is available upon request.

Storage

Preserve in the original tightly closed container under an inert atmosphere (argon or nitrogen), protected from light and moisture. Store in a cool, well-ventilated area, ideally at 2-8°C to maintain solution stability and minimize volatility. Keep away from heat, sparks, open flames, and incompatible materials such as water, acids, and oxidizing agents.

Specification

Item	Specification
Appearance	Clear, colorless to light yellow solution
Concentration	0.25 M in Tetrahydrofuran (THF)
Assay (by Titration)	0.23 - 0.27 M
Identification (IR/NMR)	Conforms to structure

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.