Description

Zaprinast CAS NO 37762-06-4 is a selective and potent inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5). This compound matters as a key biochemical tool and research intermediate for investigating cellular signaling pathways related to smooth muscle relaxation and vasodilation. It is needed by pharmaceutical R&D laboratories, academic research institutions, and fine chemical manufacturers focused on cardiovascular, pulmonary, and urological research.

Application

• Biochemical Research: Used as a selective PDE5 inhibitor to study cGMP-mediated signaling pathways in vitro and in vivo.
• Pharmaceutical Intermediate: Serves as a critical building block or reference standard in the development of novel therapeutics targeting erectile dysfunction and pulmonary arterial hypertension.
• Academic Studies: Employed in university and institutional labs for fundamental research on smooth muscle physiology, platelet aggregation, and neurotransmission.
• Preclinical Development: Utilized in animal model studies to investigate the pharmacological effects of PDE5 inhibition.
• Diagnostic Agent Development: Acts as a reference compound in the development and validation of analytical assays for PDE5 activity.
• Chemical Synthesis: Functions as a starting material or intermediate for the synthesis of more complex, proprietary PDE inhibitors.

Basic Information

Product Name	Zaprinast
CAS No.	37762-06-4
Molecular Formula	C13H13N5O2
Molecular Weight	271.28 g/mol
Synonyms	M&B 22,948; Zaprinast Hydrate; 2-o-Propoxyphenyl-8-azapurin-6-one; 1,4-Dihydro-5-(2-propoxyphenyl)-1,2,3-triazolo[4,5-d]pyrimidin-7(6H)-one; 5-(2-Propoxyphenyl)-1H-1,2,3-triazolo[4,5-d]pyrimidin-7(6H)-one; PDE5 Inhibitor I; Phenylazapurinone
EINECS	253-664-6

Quality Control

Our Zaprinast is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets high-purity standards suitable for research and development. Certificates of Analysis (COA) with detailed batch-specific results are available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.