Description

Sulfaphenazole-N2-Glucuronide is a crucial metabolite of the sulfonamide antibiotic sulfaphenazole, formed via glucuronidation. This compound is of significant importance in pharmaceutical research and development, particularly for metabolic profiling, drug interaction studies, and understanding the pharmacokinetics and clearance pathways of the parent drug. It serves as a vital reference standard for analytical laboratories in the pharmaceutical, contract research (CRO), and academic sectors, enabling precise quantification and method validation in bioanalytical assays.

Application

• Pharmaceutical Reference Standard: Primary use as a certified reference material (CRM) for the quantitative analysis of sulfaphenazole and its metabolites in biological matrices.
• Drug Metabolism & Pharmacokinetics (DMPK) Studies: Essential for investigating the metabolic fate, bioavailability, and excretion profiles of sulfaphenazole.
• Enzyme Activity Assays: Used in vitro to study the activity and inhibition of UDP-glucuronosyltransferase (UGT) enzymes involved in Phase II drug metabolism.
• Bioanalytical Method Development & Validation: A critical component for developing and validating LC-MS/MS, HPLC, or other chromatographic methods in compliance with GLP guidelines.
• Toxicological Research: Employed in studies assessing the safety and potential toxicity of drug metabolites.
• Clinical Research: Supports studies on drug-drug interactions, especially those affecting glucuronidation pathways.

Basic Information

Product Name	Sulfaphenazole-N2-Glucuronide
CAS No.	37393-47-8
Molecular Formula	C19H21N5O8S
Molecular Weight	479.47 g/mol
Synonyms	1-Sulfanilyl-2-phenylpyrazole-3-carboxamide N2-Glucuronide; Sulfaphenazole Glucuronide; N2-(β-D-Glucopyranosyluronic acid)-sulfaphenazole; Sulfaphenazole N2-β-D-Glucuronide; SPZ-Glucuronide; Sulfaphenazole Metabolite; N2-Glucuronide conjugate of Sulfaphenazole
EINECS	Contact for details

Quality Control

Our Sulfaphenazole-N2-Glucuronide is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for demanding analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity confirmation, and impurity profiles. We support research and quality assurance needs in compliance with relevant standards for reference materials.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. Keep the container in a dry, cool, and well-ventilated place. For long-term storage, consider storing desiccated at -20°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to structure
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥95.0% (Area %)
Water Content (KF)	≤5.0%
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.