Description

Thiolstatin CAS NO 37353-41-6 is a specialized sulfur-containing compound recognized for its role as a potent inhibitor of cysteine proteases. This property makes it a critical research tool and a valuable intermediate in the development of therapeutic agents targeting proteolytic pathways. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and life science sectors for enzyme inhibition studies, biochemical research, and as a building block for novel drug candidates.

Application

• Biochemical Research: Used as a selective and potent inhibitor in studies of cysteine protease enzymes like cathepsins.
• Pharmaceutical Development: Serves as a key intermediate or lead compound in the synthesis of protease inhibitor drugs.
• Enzyme Mechanism Studies: Employed to elucidate the catalytic mechanisms and biological roles of specific proteases.
• Diagnostic Reagent Formulation: Potential use in the development of diagnostic kits that measure protease activity.
• Cell Biology & Apoptosis Research: Applied in studies investigating programmed cell death where cysteine proteases are involved.
• Anti-inflammatory Agent Research: Explored for therapeutic potential in conditions mediated by excessive protease activity.

Basic Information

Product Name	Thiolstatin
CAS No.	37353-41-6
Molecular Formula	C7H12N2O3S2
Molecular Weight	236.31 g/mol
Synonyms	L-trans-Epoxysuccinyl-leucylamido(4-guanidino)butane; E-64; Epoxy-4-(guanidino)butane leucyl-epoxysuccinate; L-trans-Epoxysuccinyl-Leu-4-guanidinobutylamide; N-(N-(L-3-trans-Carboxyoxiran-2-carbonyl)-L-leucyl)-agmatine; Protease Inhibitor E-64; Cysteine Protease Inhibitor E-64
EINECS	Contact for details

Quality Control

Our Thiolstatin is produced under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot is analyzed using advanced chromatographic and spectroscopic techniques. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.