Description

Antamanide, 2-(3-Cyclohexyl-L-Alanine)-3-(3-Cyclohexyl-L-Alanine)-6-(3-Cyclohexyl-L-Alanine)-7-(3-Cyclohexyl-L-Alanine)- is a specialized cyclic decapeptide of significant interest in biochemical and pharmacological research. This compound is valued for its unique structural properties and its role as a potent inhibitor of phalloidin, a deadly toxin from the death cap mushroom. It serves as a critical research tool for scientists studying toxin mechanisms, peptide-protein interactions, and ion transport across biological membranes. This high-purity peptide is essential for advanced research in toxicology, biochemistry, and medicinal chemistry.

Application

• Biochemical Research: Used as a specific, high-affinity inhibitor in studies of phalloidin toxicity and actin polymerization dynamics.
• Pharmacological Studies: Investigated for its potential protective effects against amatoxin poisoning and its influence on cellular transport mechanisms.
• Peptide Chemistry & Drug Discovery: Serves as a model compound for studying cyclic peptide conformation, stability, and receptor binding.
• Toxicology Assays: Employed as a reference standard and active agent in developing assays for detecting and neutralizing mushroom toxins.
• Academic & Institutional Research: A key reagent for universities and research institutes focusing on natural product toxicology and peptide biology.
• Reference Standard: Used for method development, calibration, and quality control in analytical laboratories.

Basic Information

Product Name	Antamanide, 2-(3-Cyclohexyl-L-Alanine)-3-(3-Cyclohexyl-L-Alanine)-6-(3-Cyclohexyl-L-Alanine)-7-(3-Cyclohexyl-L-Alanine)-
CAS No.	37211-10-2
Molecular Formula	C64H100N10O10
Molecular Weight	1121.5 g/mol
Synonyms	Antamanide; Cyclo[[-(3-cyclohexyl-L-alanyl)-L-phenylalanyl-L-prolyl-L-prolyl-L-alanyl-L-phenylalanyl-L-prolyl-L-prolyl-]]; Phalloidin Antagonist; Antamanid; NSC 177461; Cyclic decapeptide antamanide; [Cyclo(Ala1-Phe2-Pro3-Pro4-Ala5-Phe6-Pro7-Pro8)] (where Ala = 3-cyclohexyl-L-alanine)
EINECS	Contact for details

Quality Control

Our Antamanide is produced under stringent conditions to ensure the highest standards of purity and consistency for research applications. Each batch undergoes comprehensive analytical characterization, including HPLC for purity assessment and mass spectrometry for identity confirmation. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting key specifications such as assay purity, related substances, and residual solvents. Our quality system is designed to meet the rigorous demands of pharmaceutical and biochemical research.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. This product is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere or with desiccant to maintain stability. For long-term storage, keep under argon or nitrogen. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Assay (HPLC)	≥ 95.0%
Purity (HPLC, Area %)	≥ 98.0%
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.