Description

Syntometrine is a pharmaceutical-grade combination drug primarily used in obstetrics and gynecology. Its core value proposition lies in its potent uterotonic action, which is critical for managing postpartum hemorrhage and controlling uterine atony. This product is essential for manufacturers in the global pharmaceutical industry, particularly those developing and producing critical care medications for women's health. It is supplied as a high-purity active pharmaceutical ingredient (API) to ensure efficacy and safety in final drug formulations.

Application

• Primary Pharmaceutical Ingredient: Used as the key active component in injectable formulations for the management of the third stage of labor.
• Postpartum Hemorrhage (PPH) Control: Essential in medications designed to prevent and treat excessive bleeding after childbirth.
• Uterine Atony Management: Employed in therapeutic agents to address loss of uterine muscle tone following delivery.
• Obstetric Emergency Kits: Incorporated into critical care kits and solutions used in hospital delivery rooms and maternity wards.
• Gynecological Surgery: May be used in formulations to minimize bleeding during certain surgical procedures.
• API for Generic Drug Manufacturing: Sourced by pharmaceutical companies for the production of generic versions of established uterotonic drugs.

Basic Information

Product Name	Syntometrine
CAS No.	37209-62-4
Molecular Formula	C₄₉H₆₂N₁₀O₁₀S₂
Molecular Weight	1007.2 g/mol
Synonyms	Ergometrine Maleate and Oxytocin Combination; Methylergometrine Maleate and Oxytocin; Syntometrine (Trade Name); Oxytocin and Ergometrine Maleate; Combination of Oxytocin and Methylergometrine; Postpartum Hemorrhage Combination Drug; Uterotonic Combination API; CAS 37209-62-4
EINECS	Contact for details

Quality Control

Our Syntometrine is manufactured and tested to meet stringent pharmaceutical standards. Quality assurance includes comprehensive analytical testing for identity, potency, purity, and related substances. We provide full traceability and support regulatory filings with detailed documentation. Certificates of Analysis (COA) are available upon request, confirming compliance with relevant pharmacopeial monographs (e.g., BP, EP) and cGMP guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect stability and potency. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White or almost white powder
Identification (HPLC/IR)	Conforms to standard
Assay (Oxytocin & Ergometrine)	98.0% - 102.0%
Related Substances (HPLC)	NMT 2.0% total
Individual Unknown Impurity	NMT 0.5%
Water Content (KF)	NMT 5.0%
Residue on Ignition	NMT 0.1%
Heavy Metals	NMT 20 ppm
Microbial Limits	Meets Ph. Eur. requirements

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.