Description

Mono-n-Demethyladinazolam CAS NO 37115-33-6 is a key pharmaceutical intermediate and reference standard, specifically a major metabolite of the anxiolytic agent adinazolam. This compound is of significant importance for research and development in neuropharmacology and analytical chemistry. It is primarily required by pharmaceutical manufacturers, contract research organizations (CROs), and analytical laboratories for drug metabolism studies, pharmacokinetic profiling, and as a critical standard for bioanalytical method validation.

Application

• Pharmaceutical Reference Standard: Serves as a certified primary standard for the quantitative analysis of adinazolam and its metabolites in biological matrices.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Essential for investigating the metabolic pathways, clearance, and half-life of adinazolam in preclinical and clinical research.
• Bioanalytical Method Development: Used as a critical calibrant and quality control sample in developing and validating HPLC, LC-MS, and GC-MS assays.
• Impurity Profiling: Employed to identify, quantify, and monitor this specific degradant or metabolite in active pharmaceutical ingredient (API) batches.
• Pharmacological Research: Utilized in vitro and in vivo studies to understand the activity and contribution of metabolites to the overall efficacy and safety profile of adinazolam.
• Regulatory Submissions: Provides necessary data and characterization for inclusion in regulatory filings (e.g., FDA, EMA) for drug approval.

Basic Information

Product Name	Mono-n-Demethyladinazolam
CAS No.	37115-33-6
Molecular Formula	C19H18ClN5
Molecular Weight	351.84 g/mol
Synonyms	N-Desmethyladinazolam; 8-Chloro-1-(dimethylamino)methyl-6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepine; Adinazolam Metabolite; 1-Desmethyladinazolam; Adinazolam N-Desmethyl Metabolite; U-43,465F; 4H-[1,2,4]Triazolo[4,3-a][1,4]benzodiazepine, 8-chloro-1-[(dimethylamino)methyl]-6-phenyl-
EINECS	Contact for details

Quality Control

Our Mono-n-Demethyladinazolam is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identity confirmation by spectroscopic methods (IR, NMR, MS), purity assessment by HPLC, and control of related substances and residual solvents. A detailed Certificate of Analysis (COA) is provided with each shipment, ensuring traceability and compliance with relevant standards for pharmaceutical reference materials.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing under inert atmosphere at -20°C to maximize stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%
Assay (on dried basis)	97.0% - 103.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.