Description

Icilin is a synthetic organic compound known for its potent cooling and analgesic properties, acting as a powerful agonist of the TRPM8 (Transient Receptor Potential Melastatin 8) ion channel. This makes it a critical research tool for studying thermosensation, pain pathways, and the development of novel therapeutic agents. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies focused on neuroscience, dermatology, and analgesic drug discovery.

Application

• Neuroscience Research: A key pharmacological tool for activating the TRPM8 "cold" receptor to study sensory neuron signaling, thermoregulation, and cold-induced analgesia.
• Analgesic & Drug Discovery: Serves as a reference compound and lead structure in the development of new topical cooling agents and non-opioid pain relievers.
• Dermatological Studies: Used in research to investigate skin physiology, the perception of cooling, and the formulation of cosmetic or therapeutic cooling gels.
• Physiological Pathway Mapping: Employed to elucidate the role of TRPM8 channels in various biological processes beyond cold sensation, including migraine and bladder function.
• In vitro & In vivo Assays: Essential for functional cell-based assays and animal model studies to validate TRPM8 target engagement and efficacy.

Basic Information

Product Name	Icilin
CAS No.	36945-98-9
Molecular Formula	C₁₀H₁₀Cl₂N₂O
Molecular Weight	245.10 g/mol
Synonyms	AG-3-5; Icilin; 1-[2-(2,2-Dichloro-1-hydroxycyclopentyl)vinyl]urea; 1-[2-(2,2-Dichloro-1-hydroxycyclopent-1-yl)vinyl]urea; (1E)-1-[2-(2,2-Dichloro-1-hydroxycyclopentyl)ethenyl]urea; TRPM8 Agonist (Icilin); Cooling Agent AG-3-5
EINECS	Contact for details

Quality Control

Our Icilin is manufactured under strict quality management systems to ensure high purity and batch-to-batch consistency suitable for research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity confirmation, and impurity profiles. We adhere to relevant industry standards for research chemicals, ensuring reliable and reproducible results for your critical studies.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.