Description

Dimethyl-D-Tubocurarine Iodide is a quaternary ammonium neuromuscular blocking agent derived from the natural alkaloid tubocurarine. This compound is of significant interest in pharmacological research and development due to its potent and competitive antagonism of nicotinic acetylcholine receptors at the neuromuscular junction. It serves as a critical reference standard and intermediate for researchers and manufacturers in the pharmaceutical and life sciences sectors, particularly those focused on neuropharmacology, anesthesiology, and the study of muscle relaxants.

Application

• Primary use as a pharmacological reference standard for analytical testing and method validation.
• Key research chemical in neurobiological studies investigating neuromuscular transmission and receptor function.
• Intermediate in the synthesis and development of novel neuromuscular blocking agents or related pharmaceutical compounds.
• Essential component in in-vitro bioassay systems for evaluating the potency of muscle relaxants or their antagonists.
• Used in academic and industrial R&D for studying the structure-activity relationships (SAR) of curare alkaloids.

Basic Information

Product Name	Dimethyl-D-Tubocurarine Iodide
CAS No.	36653-49-3
Molecular Formula	C₄₀H₄₈N₂O₆I₂
Molecular Weight	938.64 g/mol
Synonyms	Dimethyltubocurarine Iodide; D-Tubocurarine Dimethyl Ether Iodide; Metocurine Iodide; (+)-Tubocurarine Dimethyl Ether Iodide; Mecostrin Iodide; Dimethylcurine Iodide; (7'S,12'R)-7',12'-Bis(methyloxy)-2,2',2'-trimethyltubocuraran-6',13'-diol Diiodide; NSC 146051
EINECS	Contact for details

Quality Control

Our Dimethyl-D-Tubocurarine Iodide is produced and handled under a strict quality management system. Each batch undergoes comprehensive analytical testing, including identification, purity assay, and impurity profiling, to ensure it meets the high standards required for research and development applications. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with specified parameters.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Water Content (KF)	≤2.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.