Description

2,3,4,5,6-Pentafluorobenzene-1-Sulfonyl Fluoride is a highly reactive perfluorinated aromatic building block, serving as a key intermediate for introducing the pentafluorophenylsulfonyl (PFS) moiety. Its value lies in its dual functionality, enabling efficient derivatization for applications in pharmaceuticals, agrochemicals, and advanced materials. This compound is essential for researchers and manufacturers in life sciences and specialty chemical synthesis who require a reliable source of high-purity fluorinated synthons.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for sulfonamide-based drugs and protease inhibitors.
• Agrochemical Synthesis: Used to create novel herbicides, fungicides, and insecticides with enhanced biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a key building block for constructing sophisticated ligands and organocatalysts used in asymmetric synthesis.
• Material Science: Employed in the production of specialty polymers, liquid crystals, and electronic materials where fluorination imparts desired properties like chemical resistance and thermal stability.
• Proteomics and Biochemistry: Acts as a reactive handle for labeling and modifying proteins, peptides, and other biomolecules in research applications.
• Cross-Coupling Reactions: A valuable substrate in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to create complex fluorinated aromatic systems.

Basic Information

Product Name	2,3,4,5,6-Pentafluorobenzene-1-Sulfonyl Fluoride
CAS No.	36650-04-1
Molecular Formula	C6F6O2S
Molecular Weight	262.12 g/mol
Synonyms	Pentafluorobenzenesulfonyl Fluoride; Perfluorobenzenesulfonyl Fluoride; 2,3,4,5,6-Pentafluorophenylsulfonyl Fluoride; PFSF; Benzenesulfonyl fluoride, 2,3,4,5,6-pentafluoro-; C6F5SO2F
EINECS	Contact for details

Quality Control

Our 2,3,4,5,6-Pentafluorobenzene-1-Sulfonyl Fluoride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and FTIR, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our production adheres to cGMP guidelines where applicable, ensuring consistency and reliability for critical B2B and research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its reactivity with strong acids/organic solvents and highly volatile nature, keep away from heat, sparks, and open flame. Containers should be kept tightly sealed when not in use to prevent moisture ingress and volatilization.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.