Description

Phosphoramidon is a potent and specific metalloprotease inhibitor, widely recognized in biochemical and pharmaceutical research. This compound is essential for studying enzyme mechanisms, signal transduction pathways, and the role of metalloproteases in various physiological and pathological processes. It is a critical reagent for researchers in pharmaceutical development, academic biochemistry, and biotechnology laboratories.

Application

• Biochemical Research: As a specific inhibitor of thermolysin and other zinc metalloproteases for mechanistic studies.
• Pharmaceutical Screening: Used in high-throughput assays to identify and characterize new metalloprotease inhibitors for drug discovery.
• Cell Biology Studies: Investigation of metalloprotease functions in cellular processes such as extracellular matrix remodeling and cytokine processing.
• Enzyme Purification: Employed in affinity chromatography for the isolation and purification of specific metalloproteases.
• Neuroscience Research: Studying the role of neurolysin and other metalloproteases in neuropeptide metabolism and neurological disorders.
• Diagnostic Development: A component in diagnostic kits and assays designed to measure metalloprotease activity in clinical samples.

Basic Information

Product Name	Phosphoramidon
CAS No.	36357-77-4
Molecular Formula	C₂₃H₃₈N₄O₁₄P
Molecular Weight	622.54 g/mol
Synonyms	N-(α-L-Rhamnopyranosyloxyhydroxyphosphinyl)-L-leucyl-L-tryptophan; Phosphoramidon disodium salt; [N-(α-L-Rhamnopyranosyloxyhydroxyphosphinyl)-L-leucyl-L-tryptophan]; Thermolysin inhibitor; Protease inhibitor from *Streptomyces tanashiensis*; NSC 36357
EINECS	Contact for details

Quality Control

Our Phosphoramidon is produced under strict quality management systems to ensure batch-to-batch consistency and reliability for critical research applications. Each lot undergoes comprehensive analytical testing, including identity confirmation by spectroscopic methods and purity assessment by HPLC. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting key specifications such as assay, impurity profile, and water content.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, DMSO
Biological Activity	Inhibits thermolysin at IC₅₀ ≤ 0.5 µg/mL

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.