Description

2-Methoxy-1-Naphthylmagnesium Bromide is a highly reactive organometallic reagent, specifically a Grignard reagent, widely used in advanced organic synthesis. Its core value lies in its ability to act as a powerful nucleophile for the efficient formation of carbon-carbon bonds, enabling the construction of complex molecular architectures. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials industries, where it serves as a key building block for the synthesis of naphthalene-derived fine chemicals and active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate Synthesis: A critical reagent for introducing the 2-methoxy-1-naphthyl moiety into target molecules during the production of novel drug candidates and active pharmaceutical ingredients (APIs).
• Agrochemical Development: Used in the research and scale-up synthesis of complex herbicides, fungicides, and plant growth regulators that require naphthalene-based structures.
• Advanced Material Precursors: Serves as a building block for creating organic semiconductors, liquid crystals, and photoconductive materials used in electronics and optoelectronics.
• Fine Chemical and Fragrance Manufacturing: Employed in the synthesis of specialized naphthalene derivatives used as intermediates for dyes, pigments, and high-value aroma chemicals.
• Academic and R&D Laboratories: A valuable tool for methodological development in organic chemistry and for exploring new reaction pathways in catalytic cycles and cross-coupling reactions.
• Custom Synthesis and Contract Manufacturing: A key reagent for CDMOs (Contract Development and Manufacturing Organizations) offering bespoke chemical synthesis services to various industries.

Basic Information

Product Name	2-Methoxy-1-Naphthylmagnesium Bromide
CAS No.	36321-90-1
Molecular Formula	C11H11BrMgO
Molecular Weight	263.41 g/mol
Synonyms	1-(2-Methoxynaphthalen-1-yl)magnesium bromide; (2-Methoxynaphthalen-1-yl)magnesium bromide; 1-Bromo-2-methoxynaphthalene magnesium; 2-Methoxy-1-naphthylmagnesium bromide solution; Grignard reagent from 1-bromo-2-methoxynaphthalene; 2-Methoxy-1-naphthalenemagnesium bromide; 1-MgBr-2-MeO-naphthalene
EINECS	Contact for details

Quality Control

Our 2-Methoxy-1-Naphthylmagnesium Bromide is manufactured under stringent quality control protocols to ensure batch-to-batch consistency and reliability for sensitive synthetic applications. Each lot is analyzed to confirm identity, purity, and concentration (typically supplied as a solution in THF or diethyl ether). We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay (by titration), residual solvent content, and reactivity profile. Our quality system is designed to support cGMP and ISO standards for customers in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. This product is highly volatile, hygroscopic (moisture-sensitive), and easily oxidized (store under inert atmosphere). For optimal stability, store the sealed reagent bottle under a dry, inert atmosphere (argon or nitrogen) at recommended temperatures, typically between 2°C and 8°C for extended periods. Use appropriate ventilation and handle only in a certified fume hood. Allow the container to reach ambient temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	Brown to dark brown solution
Identification (IR)	Conforms to structure
Assay (Titration)	0.5 M in THF (or as specified)
Purity (GC/HPLC)	≥ 95% (relative area)
Water Content (Karl Fischer)	< 100 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.