Description

Propylbenzilylcholine Mustard is a potent, irreversible muscarinic acetylcholine receptor (mAChR) antagonist, widely recognized as a research-grade affinity labeling agent. Its primary value lies in its ability to form a covalent bond with the receptor, enabling detailed pharmacological studies of receptor structure, function, and distribution. This compound is essential for researchers and pharmaceutical developers in neuropharmacology, receptor biochemistry, and drug discovery programs targeting the cholinergic system.

Application

• Receptor Mapping and Characterization: Used as an irreversible ligand to study the density and localization of muscarinic acetylcholine receptors in various tissues.
• Biochemical Pharmacology Research: Employed to investigate receptor-ligand interactions, binding site topography, and the kinetics of receptor inactivation.
• Drug Discovery Tool: Serves as a key molecular tool in the development and screening of new therapeutic agents targeting mAChRs for conditions like Alzheimer's disease, COPD, and overactive bladder.
• Academic and Industrial R&D: A critical reagent in neuroscience and molecular biology laboratories for fundamental research into cholinergic signaling pathways.

Basic Information

Product Name	Propylbenzilylcholine Mustard
CAS No.	36167-80-3
Molecular Formula	C20H33ClN2O2
Molecular Weight	368.94 g/mol
Synonyms	Propylbenzilylcholine Mustard; PBCM; N-(2-Chloroethyl)-N-propyl-2-aminoethyl Benzilate; Benzilylcholine Mustard Propyl Analog; Mustard Propylbenzilylcholine; Irreversible Muscarinic Antagonist; Affinity Label for mAChR
EINECS	Contact for details

Quality Control

Our Propylbenzilylcholine Mustard is manufactured under strict quality management systems to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot undergoes comprehensive analytical testing, including HPLC purity analysis, identity confirmation (IR, NMR), and verification of biological activity. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all relevant specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to minimize oxidation. The container should be kept in a dry, well-ventilated area, away from heat and incompatible materials. Allow the product to equilibrate to room temperature in a desiccator before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.