Description

Asialoganglioside-Gm2 is a specific glycosphingolipid derivative, a key intermediate in the study of ganglioside metabolism and related biochemical pathways. This compound is of significant value in advanced life science research for investigating enzyme deficiencies, such as those in Tay-Sachs disease, and for developing diagnostic tools. It is primarily utilized by research institutions, pharmaceutical R&D departments, and diagnostic manufacturers focused on neurology, lysosomal storage disorders, and glycolipid biology.

Application

• Biochemical Research: Used as a standard or substrate in enzymatic assays to study the activity of hexosaminidases and other glycosidases.
• Disease Mechanism Studies: Critical for in vitro modeling of gangliosidoses, including Tay-Sachs and Sandhoff diseases, to understand pathology and evaluate potential therapies.
• Diagnostic Development: Serves as a key antigen or reference material in the development of immunoassays and enzymatic diagnostic kits for genetic disorders.
• Pharmaceutical R&D: Employed in drug discovery programs targeting enzyme replacement therapies (ERT) and substrate reduction therapies (SRT) for lysosomal storage diseases.
• Glycolipid Synthesis: Acts as a crucial intermediate or precursor in the chemical and enzymatic synthesis of more complex ganglioside analogs for structural-activity relationship studies.

Basic Information

Product Name	Asialoganglioside-Gm2
CAS No.	35960-33-9
Molecular Formula	C56H100N2O20
Molecular Weight	1097.4 g/mol
Synonyms	Asialo-GM2; GA2; Ganglioside GA2; Asialo-Ganglioside GM2; II3NeuAc-GgOse4Cer; β-D-Gal-(1->3)-β-D-GalNAc-(1->4)-[α-D-Neu5Ac-(2->3)]-β-D-Gal-(1->4)-β-D-Glc-(1<->1')-Ceramide; Tay-Sachs ganglioside GA2; GM2-Asialo
EINECS	Contact for details

Quality Control

Our Asialoganglioside-Gm2 is produced and handled under strict quality protocols to ensure batch-to-batch consistency and high purity for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant standards for research-grade biochemicals, ensuring reliability for your critical experiments.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to reach room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95% (Area %)
Water Content (KF)	≤ 5.0 %
Solubility	Soluble in chloroform/methanol/water mixtures

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.