Description

Piperidine-1-Sulfonyl Chloride is a versatile sulfonylating reagent and a key building block in organic synthesis. Its primary value lies in its ability to introduce the piperidine-1-sulfonyl (or "Pipsyl") group, a crucial moiety for constructing complex molecules with specific biological activities. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for creating sulfonamide-based drug candidates, enzyme inhibitors, and novel active ingredients.

Application

• Pharmaceutical Intermediate: A critical building block for synthesizing sulfonamide-based drug candidates, including protease inhibitors, kinase inhibitors, and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides that incorporate sulfonamide functional groups for enhanced efficacy.
• Chemical Biology & Proteomics: Serves as a reagent for modifying proteins, peptides, and other biomolecules to study enzyme function or create activity-based probes.
• Material Science: Employed in the synthesis of specialty polymers and functional materials where the sulfonamide linkage provides specific chemical or physical properties.
• Custom Synthesis & Contract Manufacturing: A key starting material for custom synthesis projects requiring the introduction of a protected piperidine sulfonamide moiety.
• Academic & R&D Laboratories: Fundamental reagent for methodological development in organic chemistry and for exploring new chemical spaces in medicinal chemistry programs.

Basic Information

Product Name	Piperidine-1-Sulfonyl Chloride
CAS No.	35856-62-3
Molecular Formula	C5H10ClNO2S
Molecular Weight	183.66 g/mol
Synonyms	1-Piperidinesulfonyl chloride; N-(Chlorosulfonyl)piperidine; Piperidine-1-sulfonyl chloride; Pipsyl chloride; 1-(Chlorosulfonyl)piperidine; N-Piperidylsulfonyl chloride; Piperidinosulfonyl chloride
EINECS	Contact for details

Quality Control

Our Piperidine-1-Sulfonyl Chloride is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, essential for sensitive synthetic applications. Each lot is analyzed using advanced techniques including HPLC, GC, and NMR spectroscopy. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (typically 15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition. Keep away from strong bases, oxidizing agents, and sources of ignition.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Purity (GC)	≥ 96.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.