Description

Maytansine CAS NO 35846-53-8 is a potent cytotoxic ansamycin antibiotic originally isolated from the Ethiopian shrub *Maytenus serrata*. This compound serves as a critical payload in the development of antibody-drug conjugates (ADCs), a revolutionary class of targeted cancer therapeutics. Its primary value lies in its ability to inhibit microtubule assembly, leading to cell cycle arrest and apoptosis in malignant cells. This makes it an essential intermediate and research chemical for pharmaceutical R&D, oncology research, and advanced bioconjugation processes.

Application

• Antibody-Drug Conjugate (ADC) Payload: The primary and most significant application is as the cytotoxic warhead chemically linked to monoclonal antibodies for targeted cancer therapy.
• Oncology Research: Used as a reference standard and active compound in preclinical studies to investigate mechanisms of microtubule inhibition and apoptosis.
• Pharmaceutical Intermediate: Serves as a key starting material or intermediate in the synthetic production of maytansinoid derivatives like DM1 and DM4.
• Bioconjugation Chemistry Studies: Employed in research to develop novel linker technologies and conjugation methodologies for improving ADC stability and efficacy.
• Cell Biology & Biochemistry: A tool compound for studying tubulin dynamics, mitotic spindle function, and intracellular transport mechanisms.

Basic Information

Product Name	Maytansine
CAS No.	35846-53-8
Molecular Formula	C34H46ClN3O10
Molecular Weight	692.19 g/mol
Synonyms	Maitansine; NSC 153858; Ansamitocin P-0; Antibiotic C 15003P3; (2S)-2-[[(3S,5S,6R,7S,8S,9S,15R)-15-[(2R)-2-Chloro-3-hydroxy-2-methylpropanoyl]oxy-6,8-dihydroxy-5,7,9,15-tetramethyl-2-oxo-3,16-dioxa-12-azabicyclo[12.3.1]octadeca-1(18),14,17-trien-10-yl]thio]-N,3-dimethylbutanamide; Maytansin
EINECS	Contact for details

Quality Control

Our Maytansine is produced and handled under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements for pharmaceutical research and ADC development. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting purity, related substances, and residual solvents. We support compliance with cGMP guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under an inert atmosphere when not in use to maintain stability and potency. For long-term storage, consider conditions of 2-8°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.