Description

Uridine-2-13C is a stable isotope-labeled analog of the essential nucleoside uridine, specifically enriched with carbon-13 at the 2-position of the uracil base. This precise isotopic labeling is critical for advanced research applications requiring high sensitivity and specificity in metabolic pathway tracing. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and diagnostic sectors for applications such as metabolic flux analysis, drug metabolism studies, and the development of labeled internal standards for mass spectrometry.

Application

• Metabolic Flux Analysis (MFA): Used as a tracer to study nucleotide sugar metabolism, glycosylation pathways, and cellular energetics in biological systems.
• Drug Metabolism and Pharmacokinetics (DMPK): Serves as a stable isotope-labeled internal standard for the accurate quantification of uridine and its metabolites in bioanalytical assays via LC-MS/MS.
• NMR Spectroscopy: Provides a non-radioactive, sensitive probe for investigating the structure, dynamics, and interactions of RNA and nucleoside-containing molecules.
• Biochemical Research: Enables detailed studies on pyrimidine salvage pathways, RNA synthesis, and nucleotide turnover in cell culture and in vivo models.
• Diagnostic Reagent Development: Incorporated into assay kits for the detection and monitoring of metabolic disorders related to nucleotide metabolism.

Basic Information

Product Name	Uridine-2-13C
CAS No.	35803-42-0
Molecular Formula	C9H1213CN2O6
Molecular Weight	Contact for details
Synonyms	1-β-D-Ribofuranosyl-2-13C-uracil; 2-13C-Uridine; [2-13C]Uridine; Uridine (2-13C); Isotopically labeled uridine; Carbon-13 labeled uridine; Stable isotope labeled nucleoside
EINECS	Contact for details

Quality Control

Our Uridine-2-13C is produced under stringent quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for chemical and isotopic purity, NMR for structural confirmation, and mass spectrometry. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or production specifications. Custom synthesis and purification to meet specific purity or isotopic enrichment levels are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a desiccated environment to maintain stability and prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC, NMR)	Conforms to standard
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 99 atom % 13C
Isotopic Purity (MS)	≥ 99%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.